Nanobiotechnology

Nanobioengineering

Prof. Dr. Samitier, Josep
Group Leader


Ed. Modular | Baldiri Reixac 10-12 | 08028 | Barcelona
Email : jsamitieribecbarcelona.eu

Research Topics

Microfluidics and lab-on-chip devices / Biosensor functionalisation and anion impedance sensors / Electrochemical biosensors / Nanotechnology applied to the study of bio/non-bio interfaces / Study of single biomolecule interactions


The Nanobioengineering group headed by Prof. Josep Samitier is a truly multidisciplinary team composed by researchers coming from very diverse backgrounds (chemistry, physics, material science, electronic engineering, pharmacy and molecular biology) and working together in applying nanotechnology to the development of new biomedical systems and devices, mainly for diagnostic purposes. The main activities of the group involve the physical and chemical functionalization of materials for the study of biomolecule and cell interactions and for the development of new biosensors that will be integrated in lab-on-a-chip devices. The technology and results obtained in the laboratory are employed in medical applications ranging from portable diagnosis devices to implantable prostheses for regenerative medicine purposes.


Atomic Force Microscopy image of wrinkles on a Polydimethylsiloxane (PDMS) surface, obtained after plasma oxidation and subsequent application of mechanical stress. © Juan Pablo Agusil

 

 

 

 

 

 

The projects carried out by the group are focused on clinical and industrial problems and are related to four convergent research lines:


1. Optical and electrochemical biosensors for clinical diagnosis and food safety applications

  • DNA sensors for cancer biomarker detection
  • Antibody-based sensors for pathogenic microorganisms’ detection
  • Aptamer-based sensors for toxins detection
  • Olfactory receptor-based sensors for odorant and volatile compounds detection
  • Polymer nanowires-based biosensors


2. Bio/non-bio interfaces and micro/nano-environments for biomedical studies and regenerative medicine applications

  • Design, production and characterization of micro/nanoenviroments with different biocompatible materials for cell behavior studies (adhesion, proliferation, differentiation)
  • Design, production and characterization of scaffolds with a topography and chemical composition controlled at the nanoscale for ocular and cardiac tissue regenerative therapies based on stem cells


3. Microfluidic systems for biological studies and lab-on-a-chip devices

  • Microfluidic chip for blood/plasma filtering
  • Microfluidic chip using hydrodynamic focusing for bacteria counting and sorting
  • Microfluidic chip for reagent handling in POC diagnosis devices


4. Nanotechnology applied to biomolecule interaction studies

  • Liposome based nanovectors and nanoparticles for drug delivery
  • Magnetic nanoparticles-biomolecules interactions and their applications


Schematic representation of a biosensor platform for odorant detection based on olfactory receptors.
© BOND Project