Real-time monitoring of ischemia inside stomach

Research group: Nanobiotechnology Year: 2013
Type of Publication: Article
Authors: Bogachan Tahirbegi; Mònica Mir Llorente; Josep Samitier
Journal: Biosensors & Bioelectronics Volume: 40
Number: 1 Pages: 323–328
Month: February
ISSN: 0956-5663
Journal's impact factor: 5.6
The low pH in the gastric juice of the stomach makes it difficult to fabricate stable and functional all-solid-state pH ISE sensors to sense ischemia, mainly because of anion interference and adhesion problem between the ISE membrane and the electrode surface. In this work, the adhesion of ISE membrane on solid surface at low pH was improved by modifying the surface with a conductive substrate containing hydrophilic and hydrophobic groups. This creates a stable and robust candidate for low pH applications. Moreover, anion interference problem at low pH was solved by integration of all-solid-state ISE and internal reference electrodes on an array. So, the same tendencies of anion interferences for all-solid-state ISE and all-solid-state reference electrodes cancel each other in differential potentiometric detection. The developed sensor presents a novel all-solid-state potentiometric, miniaturized and mass producible pH ISE sensor for detecting ischemia on the stomach tissue on an array designed for endoscopic applications.
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