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Dr. Xavier Fernández-Busquets
Senior Researcher

Ed. Clúster | Baldiri Reixac 10-12 | 08028 | Barcelona
T. +34 932 275 400
Email : xfernandezibecbarcelona.eu

Dr. Xavier Fernández-Busquets, senior researcher in IBEC’s Nanobioengineering group, is undertaking research into targeted nanovectors for antimalarial drug delivery with support from IBEC and the Centre de Recerca en Salut International de Barcelona (CRESIB) under an official agreement signed in 2010. This proposed the establishment of a mixed unit of personnel from both institutes aimed at developing diagnostic and therapeutic nanomedicine-based systems to be applied to malaria.

In 2011 this initiative was favourably reviewed and will continue for another three years.

For more details please visit the group page at the CRESIB website.

Publications

• Valle-Delgado, J., Urbán, P. & Fernández-Busquets, X. (2012). Demonstration of specific binding of heparin to Plasmodium falciparum-infected vs non-infected red blood cells by single-molecule force spectroscopy. Nanoscale.
• Moles, E., Urbán, P., Marques, J., Valle-Delgado, J. J., Díez, A., Prieto, B. & Fernández-Busquets, X (2012). Towards a magic bullet against malaria: Paul Ehrlich revisited. In 3rd International Conference on Nanotechnology: Fundamentals and Applications. International ASET Inc..
• Mir Llorente, M., Tahirbegi, B., Valle-Delgado, J., Fernández-Busquets, X. & Samitier, J. (2012). In vitro study of magnetite-amyloid β complex formation. Nanomedicine: Nanotechnology, Biology and Medicine, 8(6), 974-980.
• Villar-Piqué, A., de Groot, N. S., Sabaté, R., Acebrón, S. P., Celaya, G., Fernández-Busquets, X., Muga, A. & Ventura, S. (2012). The effect of amyloidogenic peptides on bacterial aging correlates with their intrinsic aggregation propensity. Journal of Molecular Biology, 421(2-3), 270-281.
• Urbán, P., Valle-Delgado, J., Moles, E., Marques, J., Díez, C. & Fernández-Busquets, X. (2012). Nanotools for the Delivery of Antimicrobial Peptides. Current Drug Targets, 13(9), 1158-1172.
• Valle-Delgado, J. J., Liepina, I., Lapidus, D., Sabaté, R., Ventura, S., Samitier, J. & Fernández-Busquets, X. (2012). Self-assembly of human amylin-derived peptides studied by atomic force microscopy and single molecule force spectroscopy. Soft Matter, 8(4), 1234-1242.
• Mir Llorente, M., Tahirbegi, B., Valle, J. J., Fernández-Busquets, X. & Samitier, J. (2012). In vitro study of magnetite-amyloid complex formation. Nanomedicine, 8(6), 974-980.
• Urbán, P., Estelrich, J., Adeva, A., Cortés, A. & Fernández-Busquets, X. (2011). Study of the efficacy of antimalarial drugs delivered inside targeted immunoliposomal nanovectors. Nanoscale Research Letters, 6(620).
• Urbán, P., Estelrich, J., Cortés, A. & Fernández-Busquets, X. (2011). A nanovector with complete discrimination for targeted delivery to Plasmodium falciparum-infected versus non-infected red blood cells in vitro. J Control Release, 151(2), 202-211.
• Valente, T., Gella, A., Fernández-Busquets, X., Unzeta, M. & Durany, N. (2010). Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus. Neurobiology of Disease, 37(1), 67 - 76.
• Valle-Delgado, J. J., Alfonso-Prieto, M., de Groot, N. S., Ventura, S., Samitier, J., Rovira, C. & Fernández-Busquets, X. (2010). Modulation of Aβ42 fibrillogenesis by glycosaminoglycan structure. The FASEB Journal, 24(11), 4250-4261.
• Bucior, I., Burger, M. M. & Fernández-Busquets, X. (2009). Carbohydrate-carbohydrate interactions. The Sugar Code. Fundamentals of Glycosciences, 22, 347-362.
• Fernández-Busquets, X., Körnig, A., Bucior, I., Burger, M. M. & Anselmetti, D. (2009). Self-Recognition and Ca2+-Dependent Carbohydrate–Carbohydrate Cell Adhesion Provide Clues to the Cambrian Explosion. Molecular Biology and Evolution, 26(11), 2551-2561.
• Giménez-Oya, V., Villacañas, Ó., Fernández-Busquets, X., Rubio-Martinez, J. & Imperial, S. (2009). Mimicking direct protein–protein and solvent-mediated interactions in the CDP-methylerythritol kinase homodimer: a pharmacophore-directed virtual screening approach. Journal of Molecular Modeling, 15, 997-1007.
• Pla, D., Sischka, A., Albericio, F., Álvarez, M., Fernández-Busquets, X. & Anselmetti, D. (2009). Optical Tweezers Study of Topoisomerase Inhibition. Small, 5(11), 1269-1272.
• Guix, F. X., Ill-Raga, G., Bravo, R., Nakaya, T., de Fabritiis, G., Coma, M., Miscione, G. P., Villà-Freixa, J., Suzuki, T., Fernández-Busquets, X., Valverde, M. A., de Strooper, B. & Muñoz, F. J. (2009). Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation. Brain, 132(5), 1335-1345.
• Bravo, R., Arimon, M., Valle-Delgado, J. J., Garcia, R., Durany, N., Castel, S., Cruz, M., Ventura, S. & Fernández-Busquets, X. (2008). Sulfated Polysaccharides Promote the Assembly of Amyloid beta1-42 Peptide into Stable Fibrils of Reduced Cytotoxicity. Journal of Biological Chemistry, 283(47), 32471-32483.
• Fernández-Busquets, X., de Groot, N. S., Fernandez, D. & Ventura, S. (2008). Recent Structural and Computational Insights into Conformational Diseases. Current Medicinal Chemistry, 15(13), 1336-1349.
• Morell, M., Bravo, R., Espargaró, A., Sisquella, X., Avilés, F. X., Fernández-Busquets, X. & Ventura, S. (2008). Inclusion bodies: Specificity in their aggregation process and amyloid-like structure. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1783(10), 1815 - 1825.
• Fernández-Busquets, X. (2007). The Sponge as a Model of Cellular Recognition (Invited Review). Sourcebook of Models for Biomedical Research (Humana Press) III, 10(75).
• Ponce, J., Fernández-Busquets, X. & Durany, N. (2006). Advanced glycation endproducts induce amyloid aggregation and reduce cell toxicity. Alzheimer’s disease: New advances, 409-412.
• Garcia-Manyes, S., Bucior, I., Ros, R., Anselmetti, D., Sanz, F., Burger, M. M. & Fernández-Busquets, X. (2006). Proteoglycan Mechanics Studied by Single-molecule Force Spectroscopy of Allotypic Cell Adhesion Glycans. Journal of Biological Chemistry, 281(9), 5992-5999.
• Garcia-Manyes, S., Bucior, I., Ros, R., Anselmetti, D., Sanz, F., Burger, M. M. & Fernández-Busquets, X. (2006). Proteoglycan Mechanics Studied by Single-molecule Force Spectroscopy of Allotypic Cell Adhesion Glycans. Journal of Biological Chemistry, 281(9), 5992-5999.