Cross-species analysis of gene regulatory networks during prostate cancer progression
Alvaro Aytés, IDIBELL
Analysis of gene regulatory networks is a powerful tool to decipher drivers of phenotypic transitions, oncogenic dependencies and potential vulnerabilities that can be exploited for therapeutic intervention. By modeling prostate cancer progression in genetically engineered mice we have been able to perform cross-species studies between mouse and human, facilitating the identification and functional validation of cancer mechanisms. In particular we have a strong interest in understanding how aberrant control of transcriptional programs leads to treatment failure and resistance in prostate cancer. Whether this results in the emergence of new dependencies and vulnerabilities is also key to envision new treatment paradigms in the era of personalized medicine.