BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Institute for Bioengineering of Catalonia - ECPv6.3.5//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-WR-CALNAME:Institute for Bioengineering of Catalonia X-ORIGINAL-URL:https://ibecbarcelona.eu/es/ X-WR-CALDESC:Eventos para Institute for Bioengineering of Catalonia REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:Europe/Madrid BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20170326T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20171029T010000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20171018T100000 DTEND;TZID=Europe/Madrid:20171018T110000 DTSTAMP:20240328T230129 CREATED:20170926T130337Z LAST-MODIFIED:20170926T130337Z UID:31498-1508320800-1508324400@ibecbarcelona.eu SUMMARY:IBEC Seminar: Arpita Upadhyaya DESCRIPTION:Push\, pull and sense: Forces and mechanosensing in immune cells\nArpita Upadhyaya\, Associate Professor\, Department of Physics\, IPST\, University of Maryland\nThe activation of lymphocytes is an essential step in the adaptive immune response. Lymphocyte activation involves the binding of specialized receptors (TCR in T cells and BCR in B cells) with antigen on the surface of antigen presenting cells. This leads to changes in cell morphology and the movement and assembly of receptors\, scaffold proteins and enzymes into signaling microclusters\, which are essential for immune cell activation. During this process\, cells of the immune system interact with structures that possess a diverse range of physical properties. I will summarize our recent studies from a biophysical perspective that examine how T cells and B cells respond to physical cues such as stiffness\, topography and ligand mobility. Specifically\, I will highlight the distinct roles of the actin and microtubule cytoskeleton in the exertion of mechanical stresses that support signaling activation\, microcluster assembly and receptor movement in T and B lymphocytes. \nShare this...FacebookPinterestTwitterLinkedin URL:https://ibecbarcelona.eu/es/event/ibec-seminar-arpita-upadhyaya/ LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain CATEGORIES:IBEC Seminar END:VEVENT END:VCALENDAR