BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Institute for Bioengineering of Catalonia - ECPv6.3.5//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-WR-CALNAME:Institute for Bioengineering of Catalonia X-ORIGINAL-URL:https://ibecbarcelona.eu X-WR-CALDESC:Events for Institute for Bioengineering of Catalonia REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:Europe/Madrid BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20200329T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20201025T010000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20200228T100000 DTEND;TZID=Europe/Madrid:20200228T120000 DTSTAMP:20240329T093159 CREATED:20200221T110843Z LAST-MODIFIED:20200221T110843Z UID:71615-1582884000-1582891200@ibecbarcelona.eu SUMMARY:PhD Discussions Sessions: Xarxa Quiroga and Adrián López DESCRIPTION:Biochemical responses to cell membrane mechanical remodelling\nXarxa Quiroga\, Cellular and molecular mechanobiology\nIn a range of physiological processes\, from extravasation to endocytosis\, cells are constantly submitted to morphological changes\, which eventually entail plasma membrane reshaping and adaptation. This remodelling could be harnessed by cells to detect and respond to shape changes\, enabling mechanosensing mechanisms. However\, how this occurs is still largely unknown.\nTo increase our understanding on how such process can happen\, we have engineered a cell-stretching system that allows us to induce controlled plasma membrane remodelling while monitoring the whole process with the help of a microscope.\nBy using this set up\, we have found that cell de-stretch triggers the formation of transient membrane evaginations whose resorption is actively regulated by BAR protein recruitment and actin polymerisation. The described process may be the first part of a molecular cascade used by cells in response to stretch. \n\nDevelopment of Microphysiological Systems for the Evaluation of Regenerative Therapies\nAdrián López\, Biomaterials for Regenerative Therapies\nThe modelling of human organs has long been a task for scientist in order to lower the costs of therapeutic development and understand the pathological onset of human disease. Animal models remain the gold standard for drug discovery\, despite their widely recognized limitations such as their marked differences with humans in terms of genetics and etiology or their high cost. \nDuring the last decade\, the advancements in tissue engineering and microfabrication gave rise to innovative models known as organs-on-a-chip or microphysiological systems\, which aim to build functional miniaturized tissues in vitro that closely mimic the actual in vivo microenvironment. In this work\, we will present two microphysiological platforms that we are developing with the goal of understanding and evaluating biomaterial-based regenerative therapies. The first model is aimed at replicating the bone healing microenvironment to evaluate the angiogenic potential of calcium-releasing scaffolds. The second model will be focused on the generation of an ischemic injury on a physiologically relevant cardiac tissue to test if lactate-releasing scaffolds are able to stimulate cardiac tissue regeneration. \nShare this...FacebookPinterestTwitterLinkedin URL:https://ibecbarcelona.eu/event/phd-discussions-sessions-xarxa-quiroga-and-adrian-lopez/ LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain CATEGORIES:PhD Discussions Session END:VEVENT END:VCALENDAR