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by Keyword: Potassium


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Gustavsson, J., Zine, N., Vocanson, F., Engel, E., Planell, J., Bausells, J., Samitier, J., Errachid, A., (2009). Characterization of potassium-selective field effect transistors based on 1,3-(di-4-oxabutanol)-calix[4]arene-crown-5 as ionophore Sensor Letters , 7, (5), 795-800

The ionophore 1,3-(di-4-oxabutanol)-calix[4]arene-crown-5 has been synthesized and used in order to develop a plasticized poly(vinyl-chloride) membrane for potassium ion detection using ion-selective field-effect transistors (ISFETs). The composition of the polymeric membrane was optimized with respect to the plasticizer being used, with the best response obtained using bis(2ethylhexyl)sebacate. The developed MEMFETs exhibit a good linear response of 52.4±1.6 mV per decade within the concentration range of 2.0 x 10-4 M to 1.0 x 10-1 M and response time of 30 seconds. The detection limit was determined to be 4 x 10-5 M and also the selectivity coefficients for possible interfering cations/anions were evaluated. The MEMFETs are suitable for use in the pH range of 3-11.

Keywords: Calix[4]arene, ISFET, MEMFET, Potassium


Gorostiza, P., Isacoff, E. Y., (2008). Optical switches for remote and noninvasive control of cell signaling Science , 322, (5900), 395-399

Although the identity and interactions of signaling proteins have been studied in great detail, the complexity of signaling networks cannot be fully understood without elucidating the timing and location of activity of individual proteins. To do this, one needs a means for detecting and controlling specific signaling events. An attractive approach is to use light, both to report on and control signaling proteins in cells, because light can probe cells in real time with minimal damage. Although optical detection of signaling events has been successful for some time, the development of the means for optical control has accelerated only recently. Of particular interest is the development of chemically engineered proteins that are directly sensitive to light.

Keywords: Ion channels, Acetylcholine receptor, Glutamate-receptor, Potassium channel, K+ channel, Light, Neurons, Channelrhodopsin-2, Manipulation, Activation