Nanobioengineering


Josep Samitier | Group Leader
David Caballero | Senior Researcher
Anna Lagunas | Senior Researcher
Mònica Mir | Senior Researcher
Margarita Alvira | Postdoctoral Researcher
Luís Botaya | PhD Student
Roberto Paoli | PhD Student
Luís G. Rigat-Brugarolas | PhD Student
Xavier Coromina | Research Assistant
Wilmer Alfonso Pardo | Research Assistant
Miriam Funes | Laboratory Technician
David Izquierdo | Laboratory Technician
Samuel Dulay | Research Technician
Judit Pérez | Masters Student
Iro Tsintzou | Masters Student

Description

The Nanobioengineering group is a truly multidisciplinary team composed by researchers coming from very diverse backgrounds (chemistry, physics, material science, electronic engineering, pharmacy and molecular biology) and working together in applying nanotechnology to the development of new biomedical systems and devices, mainly for diagnostic purposes.

samitier2014_1

The main activities of the group involve the surface functionalization of materials integrated with microfluidics systems for the study of biomolecule and cell interactions to develop Organ on Chip or for the development of new biosensors that will be integrated in lab-on-a-chip devices. The goal is to fabricate microsystems containing living cells that recapitulate tissue and organ level functions in vitro and new portable diagnosis devices that can be used as Point-of-Care systems.

The projects carried out by the group are focused on clinical and industrial problems and are related to four convergent research lines:

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Neuro Muscular Junction formation in compartmentalized microfluidic devices

Biosensors and Lab-on-a-chip for clinical diagnosis and food safety applications

  • DNA sensors and platform arrays for cancer biomarker detection
  • Antibody-based sensors for pathogenic microorganisms’ detection
  • Sensor array for in-vivo Ischemia Monitoring
  • Sensors to mimic the chemical detection of plant roots for robotic applications.
  • Microfluidic chip for reagent handling in POC diagnosis devices
  • Microfluidic chip using hydrodynamic focusing for bacteria counting and sorting
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Fluorescence images of anti-E.coli O157 antibody pattern before and after bacteria detection.

Nanotechnology applied to biomolecule interaction studies and micro/nano-environments for regenerative medicine applications

  • Design, production and characterization of micro/nanoenviroments with different biocompatible materials for cell behavior studies (adhesion, proliferation, differentiation)
  • Design, production and characterization of scaffolds with a topography and chemical composition controlled at the nanoscale for regenerative therapies based on stem cells
  • Biophysical description of cellular phenomena (cell migration, differentiation) using micro/nanotechnologies, cell biology tools and soft matter physics.
  • Magnetic nanoparticles-biomolecules interactions and their applications

Microfluidic systems for biological studies and Organ-on-Chip devices

  • Microfluidic chip for blood/plasma filtering
  • Spleen on a Chip development
  • Nanoporous based systems for kidney on chip developments.Engineering microfluidic platforms for neurobiological studies.
  • Engineering microfluidic platforms for neurobiological studies.
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Sensor array for in vivo Ischemia detection

 

News/Jobs

Josep Samitier selected as Spanish expert in bio- and nanotechnology for OECD
29/05/14

IBEC Director Josep Samitier is one of the four delegates for Spain nominated to take part in the new Working Party on Biotechnology, Nanotechnology and Converging Technologies (BNCT) of the OECD, which will start work in January 2015.


Faster and more accurate testing for causes of lower respiratory tract infections
07/04/14

Research and industry collaboration develops miniature diagnostic platform for respiratory infections such as pneumonia and infectious bronchitis Featured on the cover of the latest issue of Lab on a Chip


“Crean en España el primer bazo dentro de un chip capaz de actuar como este órgano humano”
19/03/14

The recent press release about the design of the first-ever functional 3D splenon capable of reproducing the function of the spleen, which is to filter red blood cells, by researchers from IBEC and CRESIB received lots of media coverage. Below are just a few examples.


“Càpsules de Ciència: Josep Samitier”
07/01/14

IBEC Director Josep Samitier stars in one of the Associació per a la Divulgació de la Cultura Cientifica (ADICC)’s ‘Càpsules de Ciència’, a series of videos highlighting biomedical and biotechnology researchers in Catalonia. In the video, he explains nanobiotechnology with the submarine on Ronda de Dalt as a backdrop, which represents the way nanodevices can travel through our bodies much like tiny submarines on a rescue mission.


Researchers and clinicians create first functional human ‘splenon-on-a-chip’
07/03/14

Scientists from IBEC and ISGlobal’s research centre CRESIB have designed the first-ever functional 3D splenon capable of reproducing the function of the spleen, which is to filter red blood cells.


“Nanorobots de disseny per atacar la malària”
18/11/2013

IBEC Director and Head of Nanobioengineering, Josep Samitier, and the head of the joint IBEC/CRESIB unit on Nanomalaria, Xavier Fernández-Busquets, both featured in an article in the Catalan daily newspaper Ara this weekend.


“El hombre biónico ya no es una utopía”
15/10/2013

IBEC appears in an article about bionics and rebuilding the human body published in Argentine daily newspaper El Tribuno (Salta), when Josep Samitier is quoted as an expert opinion on the subject.


IBEC researcher in first class of d·HEALTH Barcelona
25/09/2013

IBEC senior researcher Mateu Pla is one of the first class of just 12 fellows chosen for the first Design Health Barcelona (d·HEALTH Barcelona) higher education programme, which starts this week.


“El futur augura que tindrem la salut a l’abast de la mà”
31/07/2013

An interview with IBEC director Josep Samitier features in the summer edition of Alma, the magazine of the Obra Social “La Caixa”.


“Herramientas para diseñar laboratorios que caben en un chip”
16/04/2013

In this week’s Diario Medico Special on Diagnostic Therapies, IBEC acting director Josep Samitier’s expert opinion is quoted in an article about lab-on-a-chip technologies.


A promising strategy to target malaria
06/12/2012

A paper by the Nanobioengineering group reveals a new strategy for targeted malaria treatment that doesn’t rely on the use of expensive antibodies.


New generation robots – inspired by plants
12/06/2012

Last week saw the start of the three-year European project PLANTOID, of which IBEC’s Nanobioengineering group is a partner, which aims to design and develop robots inspired by plants.


A journey through the technological revolution
27/04/2012

IBEC associate director Josep Samitier officially opened the Tecnorrevolución exhibition at Barcelona’s CosmoCaixa museum last night.


“Sin un andamio de apoyo”
11/04/2011

IBEC associate director Josep Samitier is an expert opinion quoted in El Periodico last week regarding a story about a Japanese study that succeeded in growing an embryonic eye from the stem cells of mice. He describes this first successful attempt to obtain a complex three-dimensional structure spontaneously as an important breakthrough, as it opens new avenues into coaxing the growth of cells using a method that the researchers describe as an ‘inside job’ rather than using a support structure as is usually the case.


3rd BOND Consortium Meeting at IBEC
14/03/2011

The members of the BOND consortium met at IBEC at the beginning of last week for the 3rd technical meeting of the EU-funded international project.


Better tools for food safety
09/02/2011

On 2 February the kick-off meeting of a transnational project coordinated by postdoc Beatriz Prieto of the Nanobioengineering group took place at IBEC. The project, ‘Development of innovative tools for Ochratoxin A’, will evaluate and tackle the threat to humans and animals of exposure to mycotoxins (fungal metabolites) in food.


Spanish Minister for Education visits Nanobioengineering group
09/02/2011

On a tour of the Parc Científic de Barcelona (PCB) earlier this week, the Minister for Education, Ángel Gabilondo, paid a visit to IBEC’s Nanobioengineering lab and spoke at length to Associate Director Josep Samitier about his group’s research.


E-News Biocat: “Nanomedicine: Where Nanotechnology, biotechnology and the health sciences come together”
20/01/2011

IBEC associate director Josep Samitier is a contributor to the January edition of Biocat’s e-newsletter.


El Pais: “Cuestión de límites”
05/10/2010

“A Question of Limits” – an article written by associate director Josep Samitier to accompany a feature by El Pais journalist Mónica López Ferrado, “Los ‘nanoriesgos’ no son tan diminutos” (“‘Nanorisks’ are not so small’).


IBEC lends nanotech expertise to national exhibition
01/10/2010

If you’ve ever wanted to move an object using the power of your mind, predict the spread of a virus and the development of a pandemic, or watch a mini robot travel through the body to deliver a drug, you need look no further than the new Tecnorevolució exhibition, which has been created with IBEC’s associate director Josep Samitier as scientific adviser.


Famous for five minutes: TV3
23/09/2010

IBEC Project manager Juan Fran Sangüesa made the news on 22 September when he was interviewed for the midday bulletin on TV3, the Catalan television channel.


El Periódico de Catalunya: “Estamos desarrollando una nariz bioelectrónica que será capaz de diagnosticar enfermedades”
15/03/2010

In an interview, Josep Samitier, IBEC’s associated director and group leader of Nanobioengineering research group, explains the scientific basis and the development of a bioelectronic device to detect diseases.


La Vanguardia Sunday debate section: “El reto de la nanotecnología – Aportación minúscula, mejora grande”
14/03/2010

Josep Samitier, IBEC’s associated director and group leader of Nanobioengineering research group, analyzes the challenges and contributions of nanotechnology.


Novel Evolutionary Theory for the Explosion of Life
15/10/2009

The Cambrian Explosion is widely regarded as one of the most relevant episodes in the history of life on Earth, when the vast majority of animal phyla first appear in the fossil record. However, the causes of its origin have been object of debate for decades and the question of what was the trigger for the single cell microorganisms Precambrian Age (500 Mio. Years ago) to assemble and organize into multicellular organisms (Metazoans) has remained unanswered until now.


Project Kick-off for a New Bioelectronic Nose
07/10/2009

Advances in odour sensing technologies and artificial intelligence have given impetus to the use of smell in various fields, such as food safety, disease diagnosis, security, and the environment. Current electronic noses, based on electronic sensors, have considerable limitations in terms of sensitivity, reliability, and selectivity.


The Guardian Supplement: Nanotechnology 2009 – Part 2
27/08/2009

“Ask the Experts”: In an interview, Josep Samitier, Associate Director of IBEC, talks about the potential, the impact and the contributions of nanobiotechnology.


Josep Samitier appointed Rector of the University of Barcelona
21/04/2008

Josep Samitier, head of the IBEC nanobioengineering group, was appointed Acting Rector of the University of Barcelona (UB) on 21 April.


La recerca al Laboratori de Nanobioenginyeria de l’IBEC a El Periódico
15/01/2008

La recerca al Laboratori de Nanobioenginyeria de l’IBEC a El Periódico El passat dilluns 14 de gener, el diari El Periódico de Catalunya, dins la secció de Societat i Ciència, destacava la actualitat i la rellevància de la recerca en cèl·lules mare per a aplicacions terapèutiques, i concretament la recerca que es porta a terme a l’IBEC, dins el grup de recerca de Micro/nanosistemes per aplicacions biomèdiques dirigit pel Prof. Josep Samitier.


The textbook Molecular Cell Biology selects a figure from a nanobioengineering researcher at IBEC
12/07/2007

The prestigious reference textbook Molecular Cell Biology (Lodish et al.) has selected for its 6th edition (2008) a figure from the researcher at the nanobioengineering laboratory at the IBEC, Dr. Xavier Fernández-Busquets. Thanks to this important recognition of scientific excellence, the IBEC is the only Spanish institution appearing in the acknowledgements of the textbook, out of a total of 150 universitites and research centres.

Projects

EU-funded projects
PLANTOID: Innovative Robotic Artefacts Inspired by Plant Roots for Soil Monitoring ICT Josep Samitier
National projects
Universal diagnostic platforms based on oligonucleotide cofidied nanoparticles and DNA microarray sensor devices I+D-Investigación fundamental no orientada Josep Samitier

Publications

Estévez, M., Martínez, E., Yarwood, S. J., Dalby, M. J., Samitier, J., (2015??). Adhesion and migration of cells responding to microtopography Journal of Biomedical Materials Research - Part A ,

Comelles, J., Caballero, D., Voituriez, ., Hortigüelaa, V., Wollrab, V., Godeau, A. L., Samitier, J., Martínez, E., Riveline, D., (2014). Cells as active particles in asymmetric potentials: Motility under external gradients Biophysical Journal 1077, 1513-1522

Juanola-Feliu, E., Miribel-Català, P. L., Avilés, C. P., Colomer-Farrarons, J., González-Piñero, M., Samitier, J., (2014). Design of a customized multipurpose nano-enabled implantable system for in-vivo theranostics Sensors 1410, 19275-19306

Caballero, D., Samitier, J., (2014). Different strategies for the fabrication of cell culture chambers for live-cell imaging studies Chips and Tips 1412, 1-5

Oliva, A. M., Homs, A., Torrents, E., Juarez, A., Samitier, J., (2014). Effect of electric field and temperature in E.Coli viability IFMBE Proceedings Springer 41, 1833-1836

Rigat-Brugarolas, L. G., Elizalde-Torrent, A., Bernabeu, M., De Niz, M., Martin-Jaular, L., Fernandez-Becerra, C., Homs-Corbera, A., Samitier, J., Del Portillo, H. A., (2014). A functional microengineered model of the human splenon-on-a-chip Lab on a Chip 1410, 1715-1724

Castillo-Fernandez, O., Rodriguez-Trujillo, R., Gomila, G., Samitier, J., (2014). High-speed counting and sizing of cells in an impedance flow microcytometer with compact electronic instrumentation Microfluidics and Nanofluidics 161-2, 91-99

Rigat-Brugarolas, L. G., Bernabeu, M., Elizalde, A., de Niz, M., Martin-Jaular, L., Fernandez-Becerra, C., Homs-Corbera, A., del Portillo, H. A., Samitier, J., (2014). Human splenon-on-a-chip: Design and validation of a microfluidic model resembling the interstitial slits and the close/fast and open/slow microcirculations IFMBE Proceedings Springer 41, 884-887

Tahirbegi, I. B., Mir, M., Schostek, S., Schurr, M., Samitier, J., (2014). In vivo ischemia monitoring array for endoscopic surgery Biosensors and Bioelectronics 61, 124-130

Van Heirstraeten, L., Spang, P., Schwind, C., Drese, K. S., Ritzi-Lehnert, M., Nieto, B., Camps, M., Landgraf, B., Guasch, F., Corbera, A. H., Samitier, J., Goossens, H., Malhotra-Kumar, S., Roeser, T., (2014). Integrated DNA and RNA extraction and purification on an automated microfluidic cassette from bacterial and viral pathogens causing community-acquired lower respiratory tract infections Lab on a Chip 149, 1519-1526

Zaffino, R. L., Mir, M., Samitier, J., (2014). Label-free detection of DNA hybridization and single point mutations in a nano-gap biosensor Nanotechnology 2510, 105501 (8)

Lagunas, A., Castaño, A. G., Artés, J. M., Vida, Y., Collado, D., Pérez-Inestrosa, E., Gorostiza, P., Claros, S., Andrades, J. A., Samitier, J., (2014). Large-scale dendrimer-based uneven nanopatterns for the study of local arginine-glycine-aspartic acid (RGD) density effects on cell adhesion Nano Research 73, 399-409

González, L., Otero, J., Agusil, J. P., Samitier, J., Adan, J., Mitjans, F., Puig-Vidal, M., (2014). Micropattern of antibodies imaged by shear force microscopy: Comparison between classical and jumping modes Ultramicroscopy 136, 176-184

Mir, M., Lugo, R., Tahirbegi, I. B., Samitier, J., (2014). Miniaturizable ion-selective arrays based on highly stable polymer membranes for biomedical applications Sensors 147, 11844-11854

Rigat-Brugarolas, L.G., Homs, A., Samitier, J., (2014). Reservoir poly(dimethylsiloxane) cap fabrication Chips and Tips 1410, 1-4

Prieto-Simón, B., Samitier, J., (2014). "signal off" aptasensor based on enzyme inhibition induced by conformational switch Analytical Chemistry 863, 1437-1444

Rigat-Brugarolas, L.G., Homs, A., Samitier, J., (2014). Simple alignment marks patterning for multilayered master fabrication Chips and Tips 143, 1-7

Tahirbegi, I. B., Alvira, M., Mir, M., Samitier, J., (2014). Simple and fast method for fabrication of endoscopic implantable sensor arrays Sensors 147, 11416-11426

Rigat-Brugarolas, L.G., Homs, A., Samitier, J., (2014). Simple fabrication of three-dimensional ramped microstructures using SU-8 negative photoresist Chips and Tips 143, 1-5

Oliva, A. M., Homs-Corbera, A., Torrents, E., Juarez, A., Samitier, J., (2014). Synergystic effect of temperature and electric field intensity in Escherichia coli inactivation Micro and Nanosystems 62, 79-86

del Moral Zamora, B., Azpeitia, J. M. Á, Farrarons, J. C., Català, P. L. M., Corbera, A. H., Juárez, A., Samitier, J., (2014). Towards point-of-use dielectrophoretic methods: A new portable multiphase generator for bacteria concentration IFMBE Proceedings Springer International Publishing 41, 856-859

del Moral Zamora, B., Azpeitia, J. M. Á, Farrarons, J. C., Català, P. L. M., Corbera, A. H., Juárez, A., Samitier, J., (2014). Towards point-of-use dielectrophoretic methods: A new portable multiphase generator for bacteria concentration Micro and Nanosystems 62, 71-78

Lagunas, A., Comelles, J., Oberhansl, S., Hortigüela, V., Martínez, E., Samitier, J., (2013). Continuous bone morphogenetic protein-2 gradients for concentration effect studies on C2C12 osteogenic fate Nanomedicine: Nanotechnology, Biology, and Medicine 95, 694-701

Novo, S., Penon, O., Barrios, L., Nogués, C., Santaló, J., Durán, S., Gómez-Matínez, R., Samitier, J., Plaza, J. A., Pérez-García, L., Ibáñez, E., (2013). Direct embryo tagging and identification system by attachment of biofunctionalized polysilicon barcodes to the zona pellucida of mouse embryos Human Reproduction 286, 1519-1527

Caballero, D., Fumagalli, L., Teixidor, F., Samitier, J., Errachid, A., (2013). Directing polypyrrole growth by chemical micropatterns: A study of high-throughput well-ordered arrays of conductive 3D microrings Sensors and Actuators B: Chemical 177, 1003-1009

Prats-Alfonso, E., Oberhansl, S., Lagunas, A., Martínez, E., Samitier, J., Albericio, F., (2013). Effective and versatile strategy for the total solid-phase synthesis of alkanethiols for biological applications European Journal of Organic Chemistry 20137, 1233-1239

Barreiros dos Santos, M., Agusil, J. P., Prieto-Simón, B., Sporer, C., Teixeira, V., Samitier, J., (2013). Highly sensitive detection of pathogen Escherichia coli O157: H7 by electrochemical impedance spectroscopy Biosensors and Bioelectronics 451, 174-180

Tahirbegi, Islam Bogachan, Mir, Monica, Samitier, Josep, (2013). Real-time monitoring of ischemia inside stomach Biosensors and Bioelectronics 401, 323-328

Rodriguez-Segui, Santiago A., Ortuno, Maria Jose, Ventura, Francesc, Martinez, Elena, Samitier, Josep, (2013). Simplified microenvironments and reduced cell culture size influence the cell differentiation outcome in cellular microarrays Journal of Materials Science: Materials in Medicine 241, 189-198

Yang, Cheng, Lates, Vasilica, Prieto-Simón, Beatriz, Marty, Jean-Louis, Yang, Xiurong, (2012). Aptamer-DNAzyme hairpins for biosensing of Ochratoxin A Biosensors and Bioelectronics 321, 208-212

Veeregowda, D. H., van der Mei, H. C., de Vries, J., Rutland, M. W., Valle-Delgado, J. J., Sharma, P. K., Busscher, H. J., (2012). Boundary lubrication by brushed salivary conditioning films and their degree of glycosylation Clinical Oral Investigations 165, 1499-1506

Lagunas, Anna , Comelles, Jordi, Martínez, Elena, Prats-Alfonso, Elisabet , Acosta, Gerardo A., Albericio, Fernando , Samitier, Josep , (2012). Cell adhesion and focal contact formation on linear RGD molecular gradients: study of non-linear concentration dependence effects Nanomedicine: Nanotechnology, Biology and Medicine 84, 432-439

Azevedo, S., Diéguez, L., Carvalho, P., Carneiro, J. O., Teixeira, V., Martínez, E., Samitier, J., (2012). Deposition of ITO thin films onto PMMA substrates for waveguide based biosensing devices Journal of Nano Research 17, 75-83

Calò, A., Sanmartí-Espinal, M., Iavicoli, P., Persuy, M. A., Pajot-Augy, E., Gomila, G., Samitier, J., (2012). Diffusion-controlled deposition of natural nanovesicles containing G-protein coupled receptors for biosensing platforms Soft Matter 846, 11632-11643

Villar-Pique, A., De Groot, N. S., Sabaté, R., Acebrón, S. P., Celaya, G., Fernández-Busquets, X., Muga, A., Ventura, S., (2012). The effect of amyloidogenic peptides on bacterial aging correlates with their intrinsic aggregation propensity Journal of Molecular Biology 4212-3, 270-281

Villar-Pique, A., de Groot, N. S., Sabaté, R., Acebrón, S. P., Celaya, G., Fernàndez-Busquets, X., Muga, A., Ventura, S., (2012). The effect of amyloidogenic peptides on bacterial aging correlates with their intrinsic aggregation propensity Journal of Molecular Biology 4212-3, 270-281

Penon, O., Novo, S., Duran, S., Ibanez, E., Nogues, C., Samitier, J., Duch, M., Plaza, J. A., Perez-Garcia, L., (2012). Efficient Biofunctionalization of Polysilicon Barcodes for Adhesion to the Zona Pellucida of Mouse Embryos Bioconjugate Chemistry 2312, 2392-2402

Oberhansl, Sabine, Hirtz, Michael, Lagunas, Anna, Eritja, Ramon, Martinez, Elena, Fuchs, Harald, Samitier, Josep, (2012). Facile modification of silica substrates provides a platform for direct-writing surface click chemistry Small 84, 541-545

Esquivel, Juan Pablo , Castellarnau, Marc , Senn, Tobias , Löchel, Bernd , Samitier, Josep , Sabaté, Neus , (2012). Fuel cell-powered microfluidic platform for lab-on-a-chip applications Lab on a Chip 121, 74-79

Esquivel, J. P., Colomer-Farrarons, J., Castellarnau, M., Salleras, M., del Campo, F. J., Samitier, J., Miribel-Catala, P., Sabate, N., (2012). Fuel cell-powered microfluidic platform for lab-on-a-chip applications: Integration into an autonomous amperometric sensing device Lab on a Chip 1221, 4232-4235

Caballero, D., Martinez, E., Bausells, J., Errachid, A., Samitier, J., (2012). Impedimetric immunosensor for human serum albumin detection on a direct aldehyde-functionalized silicon nitride surface Analytica Chimica Acta 720, 43-48

Mir, Mònica , Tahirbegi, Islam Bogachan , Valle-Delgado, Juan José , Fernàndez-Busquets, Xavier , Samitier, Josep , (2012). In vitro study of magnetite-amyloid Nanomedicine: Nanotechnology, Biology and Medicine 86, 974-980

Rosa Hernández, M., Urbán, P., Casals, E., Estelrich, J., Escolar, G., Galán, A. M., (2012). Liposomes bearing fibrinogen could potentially interfere with platelet interaction and procoagulant activity International Journal of Nanomedicine 7, 2339-2347

Juanola-Feliu, E., Colomer-Farrarons, J., Miribel-Català , P., Samitier, J., Valls-Pasola, J., (2012). Market challenges facing academic research in commercializing nano-enabled implantable devices for in-vivo biomedical analysis Technovation 323-4, 193-204

Urban, P., Valle-Delgado, J. J., Moles, E., Marques, J., Diez, C., Fernandez-Busquets, X., (2012). Nanotools for the delivery of antimicrobial peptides Current Drug Targets 139, 1158-1172

Campas, Monica, Garibo, Diana, Prieto-Simon, Beatriz, (2012). Novel nanobiotechnological concepts in electrochemical biosensors for the analysis of toxins Analyst 1375, 1055-1067

Diéguez, Lorena, Caballero, David, Calderer, Josep, Moreno, Mauricio, Martínez, Elena, Samitier, Josep, (2012). Optical gratings coated with thin Si3N4 layer for efficient immunosensing by optical waveguide lightmode spectroscopy Biosensors 22, 114-126

Kuphal, M., Mills, C.A., Korri-Youssoufi, H., Samitier, J., (2012). Polymer-based technology platform for robust electrochemical sensing using gold microelectrodes Sensors and Actuators B: Chemical 1611, 279-284

Colomer-Farrarons, J., Miribel-Català , P., Juanola-Feliu, E., Samitier, J., (2012). A proof-of-concept of a multi-harvesting power source in a low-voltage CMOS technology IEEE Computer Society IEEE , 655-659

Gallach, D., Torres-Costa, V., García-Pelayo, L., Climent-Font, A., Martín-Palma, R. J., Barreiros-Das-Santos, M., Sporer, C., Samitier, J., Manso, M., (2012). Properties of bilayer contacts to porous silicon Applied Physics A: Materials Science and Processing 1072, 293-300

Parra-Cabrera, C., Sporer, C., Rodriguez-Villareal, I., Rodriguez-Trujillo, R., Homs-Corbera, A., Samitier, J., (2012). Selective in situ functionalization of biosensors on LOC devices using laminar co-flow Lab on a Chip 1220, 4143-4150

Valle-Delgado, J. J., Liepina, I., Lapidus, D., Sabaté, R., Ventura, S., Samitier, J., Fernàndez-Busquets, X., (2012). Self-assembly of human amylin-derived peptides studied by atomic force microscopy and single molecule force spectroscopy Soft Matter 84, 1234-1242

Tort, N., Salvador, J. P., Avino, A., Eritja, R., Comelles, J., Martinez, E., Samitier, J., Marco, M. P., (2012). Synthesis of steroid-oligonucleotide conjugates for a DNA site-encoded SPR immunosensor Bioconjugate Chemistry 2311, 2183-2191

Comelles, J., Hortiguela, V., Samitier, J., Martinez, E., (2012). Versatile gradients of covalently bound proteins on microstructured substrates Langmuir 2838, 13688-13697

Mir, M., (2011). Aptamers: The new biorecognition element for proteomic biosensing Nova Science Publishers, Inc -----, -----

Sánchez-Martín, M. J., Urbán, P., Pujol, M., Haro, I., Alsina, M. A., Busquets, M. A., (2011). Biophysical investigations of GBV-C E1 peptides as potential inhibitors of HIV-1 fusion peptide Chemphyschem 1215, 2816-2822

Juanola-Feliu, E., Colomer-Farrarons, J., Miribel-Catala, P., Samitier, J., Valls-Pasola, J., (2011). Challenges facing academic research in commercializing event-detector implantable devices for an in-vivo biomedical subcutaneous device for biomedical analysis Proceedings of the SPIE - The International Society for Optical Engineering SPIE - The International Society for Optical Engineering, USA 8067, 80670P

Punter-Villagrasa, J., Colomer-Farrarons, J., Miribel-Catala, P., Puig-Vidal, M., Samitier, J., (2011). Discrete to full custom ASIC solutions for bioelectronic applications Proceedings of the SPIE - The International Society for Optical Engineering SPIE - The International Society for Optical Engineering 8067, 80670Q

Castillo-Fernandez, Oscar, Salieb-Beugelaar, Georgette B., van Nieuwkasteele, Jan W., Bomer, Johan G., Arundell, Martin, Samitier, Josep, van den Berg, Albert, Eijkel, Jan C. T., (2011). Electrokinetic DNA transport in 20 nm-high nanoslits: Evidence for movement through a wall-adsorbed polymer nanogel Electrophoresis 3218, 2402-2409

Mir, Monica, Martinez-Rodriguez, Sergio, Castillo-Fernandez, Oscar, Homs-Corbera, Antoni, Samitier, Josep, (2011). Electrokinetic techniques applied to electrochemical DNA biosensors Electrophoresis 328, 811-821

Barthelmebs, L., Jonca, J., Hayat, A., Prieto-Simon, B., Marty, J. L., (2011). Enzyme-Linked Aptamer Assays (ELAAs), based on a competition format for a rapid and sensitive detection of Ochratoxin A in wine Food Control 225, 737-743

Valle-Delgado, J. J., Molina-Bolívar, J. A., Galisteo-González, F., Gálvez-Ruiz, M. J., (2011). Evidence of hydration forces between proteins Current Opinion in Colloid and Interface Science 166, 572-578

Ivon Rodriguez-Villarreal, Angeles, Tarn, Mark D., Madden, Leigh A., Lutz, Julia B., Greenman, John, Samitier, Josep, Pamme, Nicole, (2011). Flow focussing of particles and cells based on their intrinsic properties using a simple diamagnetic repulsion setup Lab on a Chip 117, 1240-1248

Colomer-Farrarons, Jordi , Miribel-Català, Pedro Luís, Samitier, Josep , (2011). Low-voltage µpower CMOS subcutaneous biomedical implantable device for true/false applications Biomedical Engineering ACTA Press Biomedical Engineering, 424-428

Urban, Patricia, Estelrich, Joan, Cortés, Alfred, Fernàndez-Busquets, Xavier, (2011). A nanovector with complete discrimination for targeted delivery to Plasmodium falciparum-infected versus non-infected red blood cells in vitro Journal of Controlled Release 1512, 202-211

Colomer-Farrarons, Jordi, Miribel-Català, Pere LI., Rodríguez-Villarreal, A. Ivón, Samitier, Josep, (2011). Portable bio-devices: Design of electrochemical instruments from miniaturized to implantable devices InTech Biomedical Engineering, 373-400

Rodriguez-Segui, Santiago A., Pons Ximenez, Jose Ignacio, Sevilla, Lidia, Ruiz, Ana, Colpo, Pascal, Rossi, Francois, Martinez, Elena, Samitier, Josep, (2011). Quantification of protein immobilization on substrates for cellular microarray applications Journal of Biomedical Materials Research Part A 98A2, 245-256

Fernandez, Javier G., Samitier, Josep, Mills, Christopher A., (2011). Simultaneous biochemical and topographical patterning on curved surfaces using biocompatible sacrificial molds Journal of Biomedical Materials Research Part A 98A2, 229-234

Tahirbegi, I. B., Mir, M., (2011). Slit-wave model for band structures in solid state physics Modern Physics Letters B 253, 151-161

Martinez, Elena, Samitier, Josep, (2011). Soft lithography and variants Wiley-VCH Verlag GmbH&Co -----, 57-66

Urban, Patricia, Estelrich, Joan, Adeva, Alberto, Cortes, Alfred, Fernandez-Busquets, Xavier, (2011). Study of the efficacy of antimalarial drugs delivered inside targeted immunoliposomal nanovectors Nanoscale Research Letters 61, 620

Equipment

Nanofabrication and nanomanipulation

  • Automatized microcontact printing system (custom-made)
  • Dip-Pen Nanolithography system (DPN)
  • Nanoplotter NPM
  • Nanotechnology Platform (PCB): equipment for hot embossing lithography, polymer processing and photolithography, chemical wet etching, e-beam evaporation

Characterization

  • Surface Plasmon Resonance (SPR)
  • Quartz crystal microbalance (QCM)
  • Optical Waveguide Lightmode Spectroscope (OWLS)
  • Atomic Force Microscope (AFM)
  • Optical Microscopes (white light/epifluorescence)
  • Impedance spectroscopes
  • Precision Impedance Analyzer
  • Sub-femtoamp Remote SourceMeter Instrument

Molecular/cell biology

  • Biological safety cabinet (class II)
  • Microwell plate readers
  • Protein and DNA electrophoresis systems
  • Nanodrop spectrophotometer

Microfluidics laboratory

  • High precision syringe pumps
  • Peristaltic pumps

Collaborations

 

  • Microfluidic ChipShop GmbH
  • Prof. Barbara Mazzolai IIT Center for Micro-BioRobotics (CMBR), Pontedera, Italy
  • Prof. Josep Maria Canals University of Barcelona, Spain
  • Dr. José Antonio Andrades Universidad de Málaga, Spain
  • Prof. Fernando Albericio Institut de Recerca Biomédica (IRB), Barcelona, Spain
  • Tallers Fiestas S.L.
  • Enantia S.L.
  • Biokit S.A. (Werfen group)
  • Genomica S.A.U. (Zeltia group)
  • Prof. Ramón Eritja Institut de Recerca Biomédica (IRB), Barcelona (Spain)
  • Dr. Hernando del Portillo Centro de Investigación en Salud Internacional de Barcelona (CRESIB), Barcelona (Spain)
  • Prof. Andre Bernard MNT- NTB, Buchs, Switzerland
  • Prof. Daniel Riveline ISIS/IGBMC, Strasbourg
  • Prof. Albert van den Berg University of Twente (The Netherlands)
  • Dr. Jaume Reventós Hospital Vall d’Hebrón, Barcelona (Spain)
  • Dr. Juan C. Izpisúa CMRB, Barcelona (Spain)
  • Dr. Mª Pilar Marco IIQAB-CSIC, Barcelona (Spain)
  • Dr. M. Lluïssa Pérez Dept. Farmacología, University of Barcelona (Spain)
  • Prof. Joan Bausells CNM-CSIC, Barcelona (Spain)
  • Prof. Vasco Teixeira Universidade do Minho, Braga (Portugal)
  • Prof. Jean-Louis Marty Université de Perpignan Via Domitia (France)
  • Dr. Nicole Jaffrezic Université Claude Bernard Lyon 1 (France)
  • Dr. Matthew Dalby University of Glasgow (UK)
  • Prof. Molly M. Stevens Imperial College, London (UK)
  • Dr. Graham Johnson Uniscan Instruments Ltd, Buxton (UK)
  • Prof. G. Fuhr FhG Biomedicine, St. Ingbert, Germany
  • Dr. Max M. Burger Novartis AG, Switzerland, and Marine Biological Laboratory, Woods Hole, USA
  • Prof. D. Anselmetti Universität Bielefeld, Germany
  • Prof. François Rossi JRC – ISPRA
  • Prof. M. Madou University of California at Irvine, USA
  • Prof. M. Sampietro Politecnico di Milano, Italy
  • Prof. H. Börner Max-Planck Institute of Colloids and Interfaces, Golm, Germany
  • Prof. Paolo Dario Center for Micro-BioRobotics IIT@SSSA, Pisa, Italy
  • Dr. Edith Pajot INRA, France
  • Dr. Christophe Vieu LAAS-CNRS Toulouse, France
  • Prof. E. Faszewski Wheelock College, Boston, USA
  • Prof. L. Reggiani INFM, Nanotechnology Laboratory, Lecce, Italy

 

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