Nanobiotechnology

Nanobioengineering

Prof. Dr. Samitier, Josep
Group Leader


Ed. Modular | Baldiri Reixac 10-12 | 08028 | Barcelona
Email : jsamitieribecbarcelona.eu

Research Topics

Microfluidics and lab-on-chip devices / Biosensor functionalisation and anion impedance sensors / Electrochemical biosensors / Nanotechnology applied to the study of bio/non-bio interfaces / Study of single biomolecule interactions


The Nanobioengineering group is a truly multidisciplinary team composed by researchers coming from very diverse backgrounds (chemistry, physics, material science, electronic engineering, pharmacy and molecular biology) and working together in applying nanotechnology to the development of new biomedical systems and devices, mainly for diagnostic purposes.

The main activities of the group involve the surface functionalization of materials integrated with microfluidics systems for the study of biomolecule and cell interactions to develop Organ on Chip or for the development of new biosensors that will be integrated in lab-on-a-chip devices.

The goal is to fabricate microsystems containing living cells that recapitulate tissue and organ level functions in vitro and new portable diagnosis devices that can be used as Point-of-Care systems. The projects carried out by the group are focused on clinical and industrial problems and are related to four convergent research lines:

1. Biosensors and Lab-on-a-chip for clinical diagnosis and food safety applications
  • DNA sensors for cancer biomarker detection
  • Antibody-based sensors for detection of pathogenic microorganisms
  • Olfactory receptor-based sensors for odorant and volatile compounds detection
  • Polymer nanowires-based biosensors
  • Microfluidic chip for reagent handling in POC diagnosis devices
  • Microfluidic chip using hydrodynamic focusing for bacteria counting and sorting
  • 2. Nanotechnology applied to biomolecule interaction studies and micro/nano-environments for biomedical studies and regenerative medicine applications
  • Design, production and characterization of micro/nanoenviroments with different biocompatible materials for cell behavior studies (adhesion, proliferation, differentiation)
  • Design, production and characterization of scaffolds with a topography and chemical composition controlled at the nanoscale for ocular and cardiac tissue regenerative therapies based on stem cells
  • Magnetic nanoparticles-biomolecules interactions and their applications

  • 3. Microfluidic systems for biological studies and Organ-on-Chip devices
  • Microfluidic chip for blood/plasma filtering
  • Spleen-on-a-Chip development
  • Engineering microfluidic platforms for neurobiological studies
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    Spleen organ physiology on a chip.





    Surface functionalization using dendrimers for studies of cell adhesion with non-uniform RGD density clusters. (Nano Research 2014).