Our lab aims to study human embryo implantation and provide solutions to improve in vitro fertilization (IVF).
The embryonic development of humans (and mammals in general) requires the implantation of the embryo into the walls of the mother uterus. Implantation involves the attachment of the embryo to the uterine lining, termed endometrium, and the invasion of the tissue to form the placenta.
This process is crucial for natural conception and especially for in vitro fertilization (IVF) as only 25% of IVF embryos successfully implant into the mother uterus’ and develop to term. However, despite the central role of implantation in human fertility, the process is still elusive to experimentation because of its inaccessibility.
In our lab we use bioengineering methods to create 3D environments that support embryonic development outside of the mother uterus. Our systems are accessible to imaging tools which allow us to interrogate the genetics, metabolomics and mechanics of the embryo in a high throughput manner. Using our systems we are capable to (i) improve embryo culture conditions and (ii) diagnose embryos with improved implantation potential.
Due to the high translational component of our research, we have established collaboration contracts with the pharma industry, hospitals and venture capital to bring our technology to the clinics and the market.
Our Open Lab is a multidisciplinary environment where biologists, biophysicists, clinicians and business developers synergize to create a unique environment shaped by science and entrepreneurship.
Anna Seriola Petit | Senior Researcher
Marc Casals Sandoval | Laboratory Technician
Postdoctoral researcher at the Bioengineering in Reproductive Health Open Lab
Application Deadline: 31/01/2019
The Bioengineering in reproductive health group at the Institute for Bioengineering of Catalonia (IBEC) is looking for a Postdoctoral researcher with strong imaging skills to carry out a project on hyperspectral microscopy using mammalian embryos. The contract will be within the framework of the Open Lab initiative and has strong potential to derive in a spin off venture. More information
Cutrale, Francesco, Rodriguez, Daniel, Hortigüela, Verónica, Chiu, Chi-Li, Otterstrom, Jason, Mieruszynski, Stephen, Seriola, Anna, Larrañaga, Enara, Raya, Angel, Lakadamyali, Melike, Fraser, Scott E., Martinez, Elena, Ojosnegros, Samuel, (2019). Using enhanced number and brightness to measure protein oligomerization dynamics in live cells Nature Protocols 14, 616-638
- Micromanipulation-microinjection station
- Embryo biopsy laser
- Embryo culture laboratory
- Cell culture laboratory
- Jorge Fuentes, Bussines Strategy
A_Ventures, Barcelona, Spain
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