Current smart instrumentation using multi-sensors and/or spectrometers provides a wealth of data that requires sophisticated signal and data processing approaches to extract the hidden information.
In this context, we are interested in intelligent chemical instruments for the detection of volatile compounds and smells. These systems can be based on an array of nonspecific chemical sensors with a pattern recognition engine, taking inspiration from the olfactory system. Some spectrometries, e.g. Ion Mobility Spectrometry, are capable of very fast analysis with good detection limits but poor selectivity. These technologies have been proposed for the fast determination of the volatolome (volatile fraction of the metabolome), instead of the reference technique of gas chromatography – mass spectrometry.
Our group develops algorithmic solutions for the automatic processing of Gas Sensor Array, Ion Mobility Spectrometry (IMS) and Gas Chromatography – Mass Spectrometry (GC-MS) data for metabolomics and food samples.
Our research in 2017 included the following:
- We have studied calibration transfer methods among chemical sensor arrays to reduce calibration costs.
- We have studied the impact of low power operation modes in the performance of Metal Oxide Sensors.
- We have designed methodologies to estimate the limit of detection in chemical sensors inspired in the IUPAC recommendations.
- We have been working in the detection of toxic emissions from fires to improve building occupants’ safety.
- In collaboration with Universitat de Lleida (Dr. J. Palacin) and University of Örebro (Prof. A. Lilienthal) we are testing chemical source localization algorithms with autonomous robots.
- We have been studying the use of Volatile Fingerprints for the differentiation of food products such as Iberian Ham or Bitter Oranges.
- We are developing algorithms for the analysis of mass spectrometry imaging data applied to colorectal cancer tissues.
Agustín Gutiérrez Gálvez | Senior Researcher
Lluís Fernández Romero | Postdoctoral Researcher
Jordi Fonollosa Magrinyà | Postdoctoral Researcher
Luciana Fontes de Oliveira | Postdoctoral Researcher
Silvia Mas Garcia | Postdoctoral Researcher
Javier Burgués Calderón | PhD Student
Ana Maria Solórzano Soria | PhD Student
Sergio Oller Moreno | Laboratory Technician
Researchers working at the Signal and Information Processing for Sensing Systems group and at the Nestlé Institute of Health Sciences have published a study selected as the front cover of a special issue of the journal Proteomics: Clinical Applications.
Two undergraduate biomedical engineering students who are doing their practical work at IBEC have been selected to go to Montreal to compete in SNIFFEST, a new international competition promoting practical and original solutions for odour measurement.
Former IBEC PhD student Ariadna Bartra has been awarded a Premi PIONER from CERCA.
IBEC PhD student Ana Solorzano has been selected as one of the 10 finalists from 300 participants in a “Thesis in 3 Minutes” competition that will take place at the 2016 Jornadas de Cooperación CONACyT-Catalunya (JCCC) next week.
In some research conducted with his colleagues at the University of California San Diego, IBEC senior researcher Jordi Fonollosa has shed some light on the mechanisms behind how we memorize sequences – as well as how failures in these mechanisms can provide insight into neurological disorders.
We all know how emotive smells can be; just the mere whiff of candy floss or plasticine can transport you back decades in a moment. But how does our olfactory system recognise odours even at very low doses? Now, IBEC’s Signal and Information Processing for Sensing Systems group has uncovered how we immediately and strongly identify smells even when their concentrations are very low, essentially segregating information about identification and concentration in order to be able to recognise the odour.
IBEC group leaders Alícia Casals and Santiago Marco feature in a Sunday supplement about robots in La Vanguardia this week.
A paper by IBEC’s Signal and Information Processing for Sensing Systems group and their collaborators is the featured article and appears on the cover of the latest issue of Analytica Chimica Acta.
Santiago Marco is interviewed in a video for UBTV about Somnoalert®, the mobile technology his group developed with the UB and industry partner FICOSA to detect drowsiness while driving.
PhD student Sergio Oller from the Signal and Information Processing for Sensing Systems talking about the group’s research into the development of electronic noses based on the mammalian olfactory system.
Further coverage of the driver drowsiness alerter Somnoalert® developed by IBEC and Ficosa has appeared today in El Mundo and abc.es.
Monday’s press release about the driver drowsiness alerter Somnoalert® developed by IBEC and Ficosa got lots of coverage in the news this week, including in La Vanguardia, TeleCinco and El Economista.
A new technology to combat dozing off when driving developed by IBEC, UB and industry partner Ficosa will be presented at this week’s GSMA World Mobile Congress in Barcelona.
Santiago Marco’s research group at IBEC has changed its name and will now be known as the Signal and Information Processing for Sensing Systems group.
The mammalian sense of smell is an excellent chemical sensing system that far outshines any man-made reproduction, so researchers have long been trying to analyze and recreate the animal olfactory system to develop artificial ‘noses’. Now researchers at IBEC have shed new light on this highly efficient system that could allow better chemical sensing systems with important applications in such critical areas as health, security or the food industry.
Santiago Marco elected president of ISOCS
At the General Assembly of the International Society of Olfaction and Chemical Sensing at Rockefeller University, New York, Artificial Olfaction group leader Santiago Marco was elected President of the society for a period of two years.
Last week the University of Barcelona, as a coordinator of the EU-FP7 Neurochem Project, joined with IBEC to organize the Workshop on Bioinspired Computation for Chemical Sensing, which was held on 9-11 March at the Hotel Senator in Barcelona. The focus of the workshop was on signal processing techniques inspired by the olfactory system and computational models of the biological olfactory pathway.
Wine fraud is a growing problem, with experts estimating that up to 10% of the wines offered to consumers in some European countries are of a lesser quality than the label claims. It’s an issue that affects everyone from expert collectors to average consumers, and is such a concern in some countries that drastic measures have been taken: the Italian Carabinieri Corps, for instance, has educated 25 of their officers as sommeliers.
The research team of Artificial Olfaction at IBEC, led by Santiago Marco, organized the Summer School of the International Society for Olfaction and Chemical Sensing (ISOCS). It was held from September 28th, to October 2nd of 2009, at Sant Andreu de Llavaneres, Barcelona, Spain. This Summer School was supported by the FP7 Neurochem European project, coordinated by the IBEC’s research team.
|SAFESENS Sensor Technologies for Enhanced Safety and Security of Buildings and its Occupants (2014-2017)||ENIAC Joint Undertaking||Santiago Marco|
|SIGVOL Mejora de la señal para instrumentación química: aplicaciones en metabolómica de volátiles y en olfacción (2015-2017)||MINECO, Retos investigación: Proyectos I+D||Santiago Marco|
|Development of Data Processing Algorithms for Temperature Modulated Sensors||Industrial Project with BSH Electrodomesticos, Spain||Santiago Marco|
|Computational Metabolomics (2017-2019)||Industrial Project with Nestlé Institute of Health Sciences, Switzerland||Santiago Marco|
|Analisis de tapones de corcho por espectroscopia de movilidad de iones (2015-2016)||M3C INDUSTRIAL AUTOMATION & VISION, S.L.||Santiago Marco|
|Sensor test for indoor air quality and safety applications (2015-2016)||BSH Electrodomesticos España S.A.||Santiago Marco|
|Preparació i realització d’un curs de processat de senyal per sensors químics de dos dies a BSH Zaragoza (2016-2017)||BSH Electrodomesticos España S.A.||Santiago Marco|
|SMART-IMS Procesado de Señal para Espectroscopia de Movilidad de Iones: Análisis de Fluidos Biomédicos y Detección de Sustancias Tóxicas (2012-2015)||MINECO, I+D-Investigación fundamental no orientada||Santiago Marco|
|Transducción biomimética para olfacción artificial||MINECO, EUROPA EXCELENCIA||Agustín Gutiérrez|
|BIOENCODE Estudio comparativo de la capacidad de codificación de información química de sistemas biológicos y artificiales||MINECO, I+D-Investigación fundamental no orientada||Agustín Gutiérrez|
|SENSIBLE Sensores inteligentes para edificios más seguros (2014-2016)||MINECO, Acciones de Programación Conjunta Internacional||Santiago Marco|
Oller-Moreno, Sergio, Cominetti, Ornella, Galindo, Antonio Núñez, Irincheeva, Irina, Corthésy, John, Astrup, Arne, Saris, Wim H. M., Hager, Jörg, Kussmann, Martin, Dayon, Loïc, (2018). The differential plasma proteome of obese and overweight individuals undergoing a nutritional weight loss and maintenance intervention PROTEOMICS - Clinical Applications 12, (1), 1600150
Fonollosa, Jordi, Solórzano, Ana, Marco, Santiago, (2018). Chemical sensor systems and associated algorithms for fire detection: A review Sensors 18, (2), 553
Rodríguez, R., Cortés, R., Verónica Guamán, A., Pardo, A., Torralba, Y., Gómez, F., Roca, J., Barberà, J.A., Cascante, M., Marco, S., (2018). Instrumental drift removal in GC-MS data for breath analysis: the short-term and long-term temporal validation of putative biomarkers for COPD Journal of Breath Research Accepted Manuscript online
Burgués, Javier, Marco, Santiago, (2018). Multivariate estimation of the limit of detection by orthogonal partial least squares in temperature-modulated MOX sensors Analytica Chimica Acta In Press, Accepted Manuscript
Pomareda, V., Magrans, R., Jiménez-Soto, J., Martínez, D., Tresánchez, M., Burgués, J., Palacín, J., Marco, S., (2017). Chemical source localization fusing concentration information in the presence of chemical background noise Sensors 17, (4), 904
Burgues, J., Fonollosa, J., Marco, S., (2017). Discontinuously operated MOX sensors for low power applications IEEE Conference Publications ISOCS/IEEE International Symposium on Olfaction and Electronic Nose (ISOEN) , IEEE (Montreal, Canada) , 1-3
Solorzano, A., Fonollosa, J., Fernandez, L., Eichmann, J., Marco, S., (2017). Fire detection using a gas sensor array with sensor fusion algorithms IEEE Conference Publications ISOCS/IEEE International Symposium on Olfaction and Electronic Nose (ISOEN) , IEEE (Montreal, Canada) , 1-3
Fernandez, L., Martin-Gomez, A., Mar Contreras, M., Padilla, M., Marco, S., Arce, L., (2017). Ham quality evaluation assisted by gas chromatography ion mobility spectrometry IEEE Conference Publications ISOCS/IEEE International Symposium on Olfaction and Electronic Nose (ISOEN) , IEEE (Montreal, Canada) , 1-3
Fonollosa, J., Fernández, L., Gutiérrez-Gálvez, A., Huerta, R., Marco, S., (2016). Calibration transfer and drift counteraction in chemical sensor arrays using Direct Standardization Sensors and Actuators B: Chemical 236, 1044-1053
Fernandez, L., Guney, S., Gutierrez-Galvez, A., Marco, S., (2016). Calibration transfer in temperature modulated gas sensor arrays Sensors and Actuators B: Chemical 231, 276-284
Huerta, R., Mosqueiro, T., Fonollosa, J., Rulkov, N.F., Rodríguez-Lujan, I., (2016). Online decorrelation of humidity and temperature in chemical sensors for continuous monitoring Chemometrics and Intelligent Laboratory Systems 157, 169-176
Martínez, D., Moreno, J., Tresanchez, M., Clotet, E., Jiménez-Soto, J.M., Magrans, R., Pardo, A., Marco, S., Palacín, J., (2016). Measuring gas concentration and wind intensity in a turbulent wind tunnel with a mobile robot Journal of Sensors 2016, Article ID 7184980
Ziyatdinov, Andrey, Fonollosa, Jordi, Fernández, Luis, Gutiérrez-Gálvez, Agustín, Marco, Santiago, Perera, Alexandre, (2015). Data set from gas sensor array under flow modulation Data in Brief 3, 131-136
Ziyatdinov, Andrey, Fonollosa, Jordi, Fernánndez, Luis, Gutierrez-Gálvez, Agustín, Marco, Santiago, Perera, Alexandre, (2015). Bioinspired early detection through gas flow modulation in chemo-sensory systems Sensors and Actuators B: Chemical 206, 538-547
Fonollosa, J., Sheik, S., Huerta, R., Marco, S., (2015). Reservoir computing compensates slow response of chemosensor arrays exposed to fast varying gas concentrations in continuous monitoring Sensors and Actuators B: Chemical 215, 618-629
Fernandez, L., Marco, S., Gutierrez-Galvez, A., (2015). Robustness to sensor damage of a highly redundant gas sensor array Sensors and Actuators B: Chemical 218, 296-302
Fonollosa, Jordi, Neftci, Emre, Rabinovich, Mikhail, (2015). Learning of chunking sequences in cognition and behavior Plos Computational Biology PLoS Computational Biology , 11, (11), e1004592
Maynou, Joan, Pairo, Erola, Marco, Santiago, Perera, Alexandre, (2015). Sequence information gain based motif analysis BMC Bioinformatics 16, (1), 377
Fonollosa, J., Neftci, E., Huerta, R., Marco, S., (2015). Evaluation of calibration transfer strategies between Metal Oxide gas sensor arrays Procedia Engineering EUROSENSORS 2015 , Elsevier (Freiburg, Germany) 120, 261-264
Oller-Moreno, S., Singla-Buxarrais, G., Jiménez-Soto, J. M., Pardo, Antonio, Garrido-Delgado, R., Arce, L., Marco, Santiago, (2015). Sliding window multi-curve resolution: Application to gas chromatography - Ion Mobility Spectrometry Sensors and Actuators B: Chemical 15th International Meeting on Chemical Sensors , Elsevier (Buenos Aires, Argentina) 217, 13-21
Palleja, T., Balsa, R., Tresanchez, M., Moreno, J., Teixido, M., Font, D., Marco, S., Pomareda, V., Palacin, J., (2014). Corridor gas-leak localization using a mobile Robot with a photo ionization detector sensor Sensor Letters 12, (6-7), 974-977
Fonollosa, Jordi, Vergara, Alexander, Huerta, R., Marco, Santiago, (2014). Estimation of the limit of detection using information theory measures Analytica Chimica Acta 810, 1-9
Fresco-Cala, B., Jimenez-Soto, J. M., Cardenas, S., Valcarcel, M., (2014). Single-walled carbon nanohorns immobilized on a microporous hollow polypropylene fiber as a sorbent for the extraction of volatile organic compounds from water samples Microchimica Acta 181, (9-10), 1117-1124
Marco, Santiago, (2014). The need for external validation in machine olfaction: emphasis on health-related applications Analytical and Bioanalytical Chemistry Springer Berlin Heidelberg 406, (16), 3941-3956
Polese, Davide, Martinelli, Eugenio, Marco, Santiago, Di Natale, Corrado, Gutierrez-Galvez, Agustin, (2014). Understanding odor information segregation in the olfactory bulb by means of mitral and tufted cells PLoS ONE 9, (10), e109716
Martinez, Dani, Teixidó, Mercè, Font, Davinia, Moreno, Javier, Tresanchez, Marcel, Marco, Santiago, Palacín, Jordi, (2014). Ambient intelligence application based on environmental measurements performed with an assistant mobile robot Sensors 14, (4), 6045-6055
Bennetts, Victor, Schaffernicht, Erik, Pomareda, Victor, Lilienthal, Achim, Marco, Santiago, Trincavelli, Marco, (2014). Combining non selective gas sensors on a mobile robot for identification and mapping of multiple chemical compounds Sensors 14, (9), 17331-17352
Marco, S., Gutiérrez-Gálvez, A., Lansner, A., Martinez, D., Rospars, J. P., Beccherelli, R., Perera, A., Pearce, T. C., Verschure, P. F. M. J., Persaud, K., (2014). A biomimetic approach to machine olfaction, featuring a very large-scale chemical sensor array and embedded neuro-bio-inspired computation Microsystem Technologies 20, (4-5), 729-742
Oller-Moreno, S., Pardo, A., Jimenez-Soto, J. M., Samitier, J., Marco, S., (2014). Adaptive Asymmetric Least Squares baseline estimation for analytical instruments SSD 2014 Proceedings 11th International Multi-Conference on Systems, Signals & Devices (SSD) , IEEE (Castelldefels-Barcelona, Spain) , 1569846703
Fernandez, L., Marco, S., (2014). Calibration transfer between e-noses Signal Processing and Communications Applications Conference (SIU) Signal Processing and Communications Applications Conference (SIU), 2014 22nd , IEEE (Trabzon, Turkey) , 650-653
Sheik, S., Marco, S., Huerta, R., Fonollosa, J., (2014). Continuous prediction in chemoresisitive gas sensors using reservoir computing Procedia Engineering 28th European Conference on Solid-State Transducers (EUROSENSORS 2014) , Eurosensors (Brescia, Italy) 87, 843-846
Martínez, D., Moreno, J., Tresanchez, M., Teixidó, M., Font, D., Pardo, A., Marco, S., Palacín, J., (2014). Experimental application of an autonomous mobile robot for gas leak detection in indoor environments 17th International Conference on Information Fusion (FUSION) , IEEE (Salamanca, Spain) , 1-6
Martínez, D., Moreno, J., Tresanchez, M., Teixidó, M., Palací, J., Marco, S., (2014). Preliminary results on measuring gas and wind intensity with a mobile robot in an indoor area ETFA 2014 19th IEEE International Conference on Emerging Technologies and Factory Automation , IEEE (Barcelona, Spain) , 1-5
Fernandez, L., Gutierrez-Galvez, A., Marco, S., (2014). Robustness to sensor damage of a highly redundant gas sensor array Procedia Engineering 28th European Conference on Solid-State Transducers (EUROSENSORS 2014) , Eurosensors (Brescia, Italy) 87, 851-854
Martínez, Dani, Pallejà, T., Moreno, Javier, Tresanchez, Marcel, Teixidó, M., Font, Davinia, Pardo, Antonio, Marco, Santiago, Palacín, Jordi, (2014). A mobile robot agent for gas leak source detection Advances in Intelligent Systems and Computing Trends in Practical Applications of Heterogeneous Multi-Agent Systems. The PAAMS Collection (ed. Bajo Perez, Javier, Corchado Rodríguez, Juan M., Mathieu, Philippe, Campbell, Andrew, Ortega, Alfonso, Adam, Emmanuel, Navarro, Elena M., Ahrndt, Sebastian, Moreno, Maríaa N., Julián, Vicente), Springer International Publishing 293, 19-25
Karpas, Z., Guamán, A. V., Pardo, A., Marco, S., (2013). Comparison of the performance of three ion mobility spectrometers for measurement of biogenic amines Analytica Chimica Acta 758, (3), 122-129
Pomareda, Victor, Lopez-Vidal, Silvia, Calvo, Daniel, Pardo, Antonio, Marco, Santiago, (2013). A novel differential mobility analyzer as VOCs detector and multivariate techniques for identification and quantification Analyst 138, (12), 3512-3521
Ziyatdinov, A., Diaz, E. Fernández, Chaudry, A., Marco, S., Persaud, K., Perera, A., (2013). A software tool for large-scale synthetic experiments based on polymeric sensor arrays Sensors and Actuators B: Chemical 177, 596-604
Fonollosa, Jordi, Fernérndez, Luis, Huerta, Ramón, Gutiérrez-Gálvez, Agustín, Marco, Santiago, (2013). Temperature optimization of metal oxide sensor arrays using Mutual Information Sensors and Actuators B: Chemical Elsevier 187, (0), 331-339
Marco, S., Gutiérrez-Gálvez, A., Lansner, A., Martinez, D., Rospars, J. P., Beccherelli, R., Perera, A., Pearce, T., Vershure, P., Persaud, K., (2013). Biologically inspired large scale chemical sensor arrays and embedded data processing Proceedings of SPIE - The International Society for Optical Engineering Smart Sensors, Actuators, and MEMS VI , SPIE Digital Library (Grenoble, France) 8763, 1-15
Santano-Martínez, R., Leiva-González, R., Avazbeigi, M., Gutiérrez-Gálvez, A., Marco, S., (2013). Identification of molecular properties coding areas in rat's olfactory bulb by rank products Proceedings of the International Conference on Bio-Inspired Systems and Signal Processing BIOSIGNALS 2013 , SciTePress (Barcelona, Spain) , 383-387
Fernandez, L., Gutierrez-Galvez, A., Marco, S., (2013). Multi-way analysis of diversity and redundancy factors in large MOX gas sensor data Metal Oxide-based Sensors 14th International Meeting on Chemical Sensors - IMCS 2012 , AMA Science Portal (Nuremberg, Germany) P2.07, 1279-1280
Hernandez Bennetts, V. M., Lilienthal, A. J., Khaliq, A. A., Pomareda Sese, V., Trincavelli, M., (2013). Towards real-world gas distribution mapping and leak localization using a mobile robot with 3d and remote gas sensing capabilities 2013 IEEE International Conference on Robotics and Automation (ICRA) (ed. Parker, Lynne E.), IEEE (Karlsruhe, Germany) , 2335-2340
Gutiérrez-Gálvez, A., Marco, S., (2013). Study of the coding efficiency of populations of olfactory receptor neurons and olfactory glomeruli Frontiers in Neuroengineering Series Neuromorphic Olfaction (ed. Persaud, K. , Marco, S., Gutiérrez-Gálvez, A.), CRC Press (London, UK) , 59-82
Persaud, K. , Marco, S., Gutiérrez-Gálvez, A., (2013). Neuromorphic Olfaction Frontiers in Neuroengineering Series Neuromorphic Olfaction , CRC Press (London, UK)
- Gas chromatograph/mass spectrometer (Thermoscientific) with robotic head-space sampler
- Gas Chromatograph/ Thermal Conductivity Detector (Thermoscientific) with robotic head-space sampler
- 2 Infusion pumps K-systems
- 6 channel vapor generator plus humidity control (Owlstone, UK)
- Ion Mobility Spectrometer: Gas Detector Array (Airsense Analytics GmbH)
- Computing and General Purpose Electronic Instrumentation
- Field Asymmetric Ion Mobility Spectrometer (Owlstone, UK)
- Corona Discharge Ion Mobility Spectrometer (3QBD, Israel)
- Ultraviolet Ion Mobility Spectrometer (Gas Dortmund, Germany)
- Fast Photo Ionization Detector (Aurora Scientific, Canada)
- Dr. Lourdes Arce
Dept. Química Analítica, Universidad de Córdoba, Spain
- Prof. J. W. Gardner
Microsensors and Bioelectronics Lab, Dept. of Electric and Electronic Engineering, University of Warwick, UK
- Prof. Achim Lilienthal
Mobile Robotics and Olfaction Lab, University of Örebro, Sweden
- Dr. Ivan Montoliu and Dra. Sofia Moço
Nestlé Institute of Health Sciences, Laussane, Switzerland
- Dr. Jordi Palacín
Robotics Lab, Universitat de Lleida, Spain
- Dra. Cristina Castro
Sensors Technology, BSH-Zaragoza, Spain
- Dr. Jens Eichman
MINIMAX, Bad Oldesloe, Germany
- Dr. Ulf Struckmeier
AMS sensors, Reutlingen, Germany
- Dr. Fernando Azpiroz
Dept. Digestive Diseases, Vall d’Hebron, Barcelona, Spain
- Dra. Anna de Juan
Dept. Química Analítica i Enginyeria Química, Universitat de Barcelona, Spain