Internationalization is at the core of IBEC’s scientific and training strategy. Actions enhancing IBEC’s international profile are designed to foster exchange in complementary techniques and trigger new collaborations, as well as to place the institute as an international reference centre in bioengineering.
Mobility plays a key role in research training and career development. Interaction with outstanding complementary researchers, either during stays outside IBEC or by bringing people into IBEC, is essential for the training of staff at all levels.
Thanks to existing mobility schemes, IBEC researchers can enjoy intense transnational and multidisciplinary exchange, as well as the expertise and facilities of the best institutions worldwide. In addition, mobility is the seed for future collaboration and joint projects, and serves to expand the international network of research institutions linked to IBEC.
In the framework of the Severo Ochoa programme, IBEC has launched two new internationalization programmes at Group Leader level: the visiting programme for outstanding external researchers, and the sabbatical programme for internal researchers.
Severo Ochoa Visiting programme for external outstanding researchers
IBEC will implement, starting February 2017, an annual call for IBEC group leaders to propose visitors. In principle, visitors should stay at least three months, unless exceptional circumstances apply.
Candidate should be PIs of their own research lab and have an outstanding international profile. IBEC’s directorate will evaluate the proposals based on the merits of the candidate, the relevance of the project and the added value of the stay for the hosting research group and IBEC.
Depending on the number of proposals positively evaluated and the complementary cofunding secured by the candidate/group leader, IBEC will co‐fund each visitor’s stay. The level of cofunding will range from the travel expenses to come to Barcelona, to a stipend of 2.000€ per month for three months.
In every case, IBEC will provide its selected visitors with office space and the assistance of IBEC’s support staff. Laboratory space, if needed, should be provided by the hosting research group.
During their stay, meetings with interested group leaders will be organized to explore ideas for collaboration, and each visitor will give a seminar to the whole IBEC community to present their research.
At the end of the stay, the hosting group leader will provide a short report about the activities carried out and the benefits obtained.
- 2017 call: For stays planned from 1‐3‐2017 to 30‐6‐2018
- Launch of the call: 21 February 2017
- Deadline of the call: 5 May 2017
- 2018 call: For stays planned from 1‐1‐2018 to 30‐6‐2019
- Launch of the call: 1st December 2017
- Deadline of the call: 31 January 2018
Application form: Severo Ochoa Visiting programme for outstanding external researchers
Applications should be sent to email@example.com together with a CV of the candidate before 31st January 2018. Applications will be evaluated as they are received, so you are encouraged not to wait until the application deadline.
Severo Ochoa Sabbatical programme
** 2nd call opens 1st December 2017 **
IBEC will implement, starting February 2017, an annual call for its Sabbatical Programme for its group leaders, who are encouraged to take sabbatical leave at internationally recognized institutions where they can establish new collaborations and explore unconventional paths that boost their current research.
IBEC’s directorate will evaluate the proposals based on the relevance of the project and the added value of the stay for the group leader and IBEC. In principle, sabbatical leave should last at least three months, unless exceptional circumstances apply.
Depending on the number of proposals positively evaluated, IBEC will co‐fund each sabbatical stay with a maximum of a stipend of 1.000€ per month for six months, plus travel expenses. The funding may be used to cover teaching duties during the stay.
During their sabbatical leave, the group leader will be asked to give a seminar at the hosting institution. At the end of the leave, the group leader will provide a short report about activities carried out and the benefits obtained, as well as giving a seminar at IBEC about their experience.
- 2017 call: For sabbatical stays planned from 1‐3‐2017 to 30‐6‐2018
- Launch of the call: 21 February 2017
- Deadline of the call: 5 May 2017
- 2018 call: For sabbatical stays planned from 1‐1‐2018 to 30‐6‐2019
- Launch of the call: 1st December 2017
- Deadline of the call: 31 January 2018
Application form: Severo Ochoa Sabbatical programme
Applications should be sent to firstname.lastname@example.org before 31st January 2018. Applications will be evaluated as they are received, so you are encouraged not to wait until the application deadline.
IBEC group hosts liver specialist
Xavier Trepat’s Integrative Cell and Tissue Dynamics group is hosting Prof. Jonel Trebicka, Head of the University of Bonn’s Laboratory for Liver Fibrosis and Portal Hypertension in its Department of Internal Medicine, during 2017. During his stay, he will study the mechanobiology of stellate cells in liver fibrosis, harnessing the expertise of the IBEC group in cell mechanics and migration, including traction force and confocal microscopy, durotaxis assays and magnetic cytometry.
His stay at IBEC is funded by the foundation EF-CLIF, the European Foundation for the Study of Chronic Liver Failure.
IBEC group collaborates with microfluidics expert on intelligent delivery systems
Prof. Dong-Pyo Kim, Head of the Center of Intelligent Microfluidic Pharmaceutical Synthesis at POSTECH (Pohang University of Science & Technology) in Korea is spending a six-month research stay in Samuel Sánchez’s Smart nano-bio-devices group at IBEC.
Prof Kim is a world expert in microfluidics, and his collaboration with the IBEC group will aim to develop unique functional drug delivery systems that take advantage of the excellent heat/mass transfer in microfluidics. The ultimate goal of the collaboration will be to develop an intelligent synthetic microreactor system for highly efficient ‘one-flow’, ‘feed-to-end’ production of active pharmaceutical ingredients.
The work will involve creating a microrobot – for which Samuel’s group is key –that will be synthesized by microfluidic systems and in situ loaded drugs into micro- or nanoscaled carriers with self-actuating functions. It’s hoped that by the end of the project, the researchers will be at the stage of assessing the bot’s function in a biomimetic blood vessel.
Prof Kim, who has also worked in the USA and been a visiting professor in Europe and Japan, is the winner of many accolades including the National Research Foundation (NRF)’s Scientist of the Month in 2016 and the Korean Chemical Society’s Academic Excellence Award in 2017.
Surfaces experts join forces
Fabio Variola, Associate Professor at the University of Ottawa (Canada), is spending 2017 in the Biomimetic Systems for Cell Engineering group. Having created, for the first time ever, a 3-dimensional hierarchical surface that mimics biologically successful life-forms such as marine diatoms or unicellular algae, Dr. Variola is collaborating with Elena Martinez and her group to determine the bioactive properties of this surface.
By working together at IBEC, Dr. Variola’s experimental knowledge of synthetic nanostructured surfaces and Elena’s extensive experience in biomimetic ones is hoped to lead to new advances in understanding nanoscale hierarchical structures in nature, as these underlie the development of both normal and pathological conditions. The ultimate aim is to develop new diagnostic tools and approaches for health-related research.
Lange, C. M., Bechstein, W. O., Berg, T., Engelmann, C., Bruns, T., Canbay, A., Moreau, R., Trebicka, J., (2018). Acute-on-chronic liver failure Visceral Medicine , 34, (4), 296-300
Trebicka, J., Reiberger, T., Laleman, W., (2018). Gut-liver axis links portal hypertension to acute-on-chronic liver failure Visceral Medicine , 34, (4), 270-275
Magdaleno, Fernando, Schierwagen, R., Uschner, Frank E., Trebicka, J., (2018). “Tipping” extracellular matrix remodeling towards regression of liver fibrosis: novel concepts Minerva Gastroenterologica e Dietologica , 64, (1), 51-61
Schierwagen, Robert, Alvarez-Silva, Camila, Madsen, Mette Simone Aae, Kolbe, Carl Christian, Meyer, Carsten, Thomas, Daniel, Uschner, Frank Erhard, Magdaleno, Fernando, Jansen, Christian, Pohlmann, Alessandra, Praktiknjo, Michael, Hischebeth, Gunnar T., Molitor, Ernst, Latz, Eicke, Lelouvier, Benjamin, Trebicka, Jonel, Arumugam, Manimozhiyan, (2018). Circulating microbiome in blood of different circulatory compartments Gut , In press,
Luetkens, Julian A., Klein, Sabine, Traeber, Frank, Schmeel, Frederic C., Sprinkart, Alois M., Kuetting, Daniel L. R., Block, Wolfgang, Hittatiya, Kanishka, Uschner, Frank E., Schierwagen, Robert, Gieseke, Juergen, Schild, Hans H., Trebicka, Jonel, Kukuk, Guido M., (2018). Quantitative liver MRI including extracellular volume fraction for non-invasive quantification of liver fibrosis: a prospective proof-of-concept study Gut , 67, (3), 593-594
Pose, Elisa, Trebicka, Jonel, Mookerjee, Rajeshwar P., Angeli, Paolo, Ginès, Pere, (2018). Statins: Old drugs as new therapy for liver diseases? Journal of Hepatology , In press,
Praktiknjo, M., Book, M., Luetkens, J., Pohlmann, A., Meyer, C., Thomas, D., Jansen, C., Feist, A., Chang, J., Grimm, J., Lehmann, J., Strassburg, C. P., Abraldes, J. G., Kukuk, G., Trebicka, J., (2018). Fat-free muscle mass in magnetic resonance imaging predicts acute-on-chronic liver failure and survival in decompensated cirrhosis Hepatology , 67, (3), 1014-1026
Jansen, Christian, Möller, Philipp, Meyer, Carsten, Kolbe, Carl Christian, Bogs, Christopher, Pohlmann, Alessandra, Schierwagen, Robert, Praktiknjo, Michael, Abdullah, Zeinab, Lehmann, Jennifer, Thomas, Daniel, Strassburg, Christian P., Latz, Eicke, Mueller, Sebastian, Rössle, Martin, Trebicka, Jonel, (2018). Increase in liver stiffness after transjugular intrahepatic portosystemic shunt is associated with inflammation and predicts mortality Hepatology , 67, (4), 1472-1484
Piano, Salvatore, Schmidt, Hartmut H., Ariza, Xavier, Amoros, Alex, Romano, Antonietta, Hüsing-Kabar, Anna, Solà , Elsa, Gerbes, Alexander, Bernardi, Mauro, Alessandria, Carlo, Scheiner, Bernhard, Tonon, Marta, Maschmeier, Miriam, Solè, Cristina, Trebicka, Jonel, Gustot, Thierry, Nevens, Frederik, Arroyo, Vicente, Gines, Pere, Angeli, Paolo, (2018). Association between grade of acute on chronic liver failure and response to terlipressin and albumin in patients with hepatorenal syndrome Clinical Gastroenterology and Hepatology , 16, (11), 1792-1800
Julian, A. Luetkens, Sabine, Klein, Frank, Träber, Frederic, C. Schmeel, Alois, M. Sprinkart, Daniel, L. R. Kuetting, Wolfgang, Block, Frank, E. Uschner, Robert, Schierwagen, Kanishka, Hittatiya, Glen, Kristiansen, Juergen, Gieseke, Hans, H. Schild, Jonel, Trebicka, Guido, M. Kukuk, (2018). Quantification of liver fibrosis at T1 and T2 mapping with extracellular volume fraction MRI: Preclinical results Radiology , 288, (3), 748-754
Beiert, T., Knappe, V., Tiyerili, V., Stöckigt, F., Effelsberg, V., Linhart, M., Steinmetz, M., Klein, S., Schierwagen, R., Trebicka, J., Roell, W., Nickenig, G., Schrickel, J. W., Andrié, R. P., (2018). Chronic lower-dose relaxin administration protects from arrhythmia in experimental myocardial infarction due to anti-inflammatory and anti-fibrotic properties International Journal of Cardiology , 250, 21-28
Lehmann, Jennifer M., Claus, Karina, Jansen, Christian, Pohlmann, Alessandra, Schierwagen, Robert, Meyer, Carsten, Thomas, Daniel, Manekeller, Steffen, Claria, Joan, Strassburg, Christian P., Trautwein, Christian, Wasmuth, Hermann E., Berres, Marie-Luise, Trebicka, Jonel, (2018). Circulating CXCL10 in cirrhotic portal hypertension might reflect systemic inflammation and predict ACLF and mortality Liver International , 38, (5), 875-884
Schwabl, Philipp, Brusilovskaya, Ksenia, Supper, Paul, Bauer, David, Königshofer, Philipp, Riedl, Florian, Hayden, Hubert, Fuchs, Claudia Daniela, Stift, Judith, Oberhuber, Georg, Aschauer, Stefan, Bonderman, Diana, Gnad, Thorsten, Pfeifer, Alexander, Uschner, Frank Erhard, Trebicka, Jonel, Rohr-Udilova, Nataliya, Podesser, Bruno Karl, Peck-Radosavljevic, Markus, Trauner, Michael, Reiberger, Thomas, (2018). The soluble guanylate cyclase stimulator riociguat reduces fibrogenesis and portal pressure in cirrhotic rats Scientific Reports , 8, (1), 9372
Ruiz-Margáin, Astrid, Pohlmann, Alessandra, Ryan, Patrick, Schierwagen, Robert, Chi-Cervera, Luis A., Jansen, Christian, Mendez-Guerrero, Osvely, Flores-García, Nayelli C., Lehmann, Jennifer, Torre, Aldo, Macías-Rodríguez, Ricardo Ulises, Trebicka, Jonel, (2018). Fibroblast growth factor 21 is an early predictor of acute-on-chronic liver failure in critically ill patients with cirrhosis Liver Transplantation , 24, (5), 595-605
Jansen, Christian, Cox, Alexander, Schueler, Robert, Schneider, Matthias, Lehmann, Jennifer, Praktiknjo, Michael, Pohlmann, Alessandra, Chang, Johannes, Manekeller, Steffen, Nickenig, Georg, Berlakovich, Gabriela, Strassburg, Christian P., Hammerstingl, Christoph, Staufer, Katharina, Trebicka, Jonel, (2018). Increased myocardial contractility identifies patients with decompensated cirrhosis requiring liver transplantation Liver Transplantation , 24, (1), 15-25
Trebicka, Jonel, (2018). Non-cirrhotic portal hypertension: A possibly benign but complicated disease Digestive and Liver Disease , 50, (8), 845-846
Anadol, Evrim, Lust, Kristina, Boesecke, Christoph, Schwarze-Zander, Carolynne, Mohr, Raphael, Wasmuth, Jan-Christian, Rockstroh, Jürgen Kurt, Trebicka, Jonel, (2018). Exposure to previous cART is associated with significant liver fibrosis and cirrhosis in human immunodeficiency virus-infected patients PLoS ONE , 13, (1), e0191118
Jansen, Christian, Al-Kassou, Baravan, Lehmann, Jennifer, Pohlmann, Alessandra, Chang, Johannes, Praktiknjo, Michael, Nickenig, Georg, Strassburg, Christian P., Schrickel, Jan W., Andrié, René, Linhart, Markus, Trebicka, Jonel, (2018). Severe abnormal Heart Rate Turbulence Onset is associated with deterioration of liver cirrhosis PLoS ONE , 13, (4), e0195631
Madsen, Bjørn Stæhr, Trebicka, Jonel, Thiele, Maja, Israelsen, Mads, Arumugan, Manimozhiyan, Havelund, Troels, Krag, Aleksander, (2018). Antifibrotic and molecular aspects of rifaximin in alcoholic liver disease: study protocol for a randomized controlled trial Trials , 19, (1), 143
Mohr, Raphael, Boesecke, Christoph, Dold, Leona, Schierwagen, Robert, Schwarze-Zander, Carolynne, Wasmuth, Jan-Christian, Weisensee, Insa, Rockstroh, Jürgen Kurt, Trebicka, Jonel, (2018). Return-to-health effect of modern combined antiretroviral therapy potentially predisposes HIV patients to hepatic steatosis Medicine , 97, (17), e0462
Laleman, Wim, Claria, Joan, Van der Merwe, Schalk, Moreau, Richard, Trebicka, Jonel, (2018). Systemic inflammation and acute-on-chronic liver failure: Too much, not enough Canadian Journal of Gastroenterology and Hepatology , 2018, 10
Trebicka, J., Gluud, L. L., (2017). Reply to: “Adding embolization to TIPS implantation: A better therapy to control bleeding from ectopic varices?” Journal of Hepatology , 67, (1), 202-203
Jansen, C., Thiele, M., Verlinden, W., Krag, A., Francque, S., Trebicka, J., (2017). Prediction of presence of oesophageal varices just by shear-wave elastography of the liver and spleen Liver International , 37, (9), 1406-1407
Reiberger, T., Trebicka, J., (2017). New liver – Fresh microbiome: Implications on brain function Liver Transplantation , 23, (7), 873-874
Schierwagen, R., Uschner, F. E., Magdaleno, F., Klein, S., Trebicka, J., (2017). Rationale for the use of statins in liver disease American Journal of Physiology - Gastrointestinal and Liver Physiology , 312, (5), G407-G412
Beiert, T., Tiyerili, V., Knappe, V., Effelsberg, V., Linhart, M., Stöckigt, F., Klein, S., Schierwagen, R., Trebicka, J., Nickenig, G., Schrickel, J. W., Andrié, R. P., (2017). Relaxin reduces susceptibility to post-infarct atrial fibrillation in mice due to anti-fibrotic and anti-inflammatory properties Biochemical and Biophysical Research Communications , 490, (3), 643-649
Schwab, S., Lehmann, J., Lutz, P., Jansen, C., Appenrodt, B., Lammert, F., Strassburg, C. P., Spengler, U., Nischalke, H. D., Trebicka, J., (2017). Influence of genetic variations in the SOD1 gene on the development of ascites and spontaneous bacterial peritonitis in decompensated liver cirrhosis European Journal of Gastroenterology and Hepatology , 29, (7), 800-804
Klein, S., Schierwagen, R., Uschner, F. E., Trebicka, J., (2017). Mouse and rat models of induction of hepatic fibrosis and assessment of portal hypertension Fibrosis (Methods in Molecular Biology) (ed. Rittié, L.), Humana Press (New York, USA) 1627, 91-116