The Biosensors for bioengineering group is a junior group under IBEC’s Tenure Track scheme.
Javier Ramón Azcón | Junior Group Leader ICREA
Francesco De Chiara | Postdoctoral Researcher
Juanma Fernandez Costa | Postdoctoral Researcher
Gerardo López Muñoz | Postdoctoral Researcher
Irene Marco Rius | Postdoctoral Researcher
Maria Alejandra Ortega Machuca | Postdoctoral Researcher
Júlia Rodríguez Comas | Postdoctoral Researcher
José Yeste Lozano | Postdoctoral Researcher
Marc Azagra Rodríguez | PhD Student
Laura Clua Ferré | PhD Student
Xiomara Gislen Fernández Garibay | PhD Student
Ferran Velasco Mallorquí | PhD Student
Natalia Kovaleva Dorozhkina | Masters Student
Jordina Balaguer Trias | Laboratory Assistant
Ainhoa Ferret Miñana | Laboratory Assistant
Rodrigo Alvarez Velasco | Visiting Researcher
Drug discovery pathway relies heavily on in vivo animal models and in vitro cell mediums. In the case of animal models we have not only some ethical problems but also the ability to extrapolate data to human conditions is limited and in vitro platforms often do not simulate the complex cell–cell and cell–matrix interactions crucial for regulating cell behaviour.
Biosensors for bioengineering group is focused in a new line of research that has become of extreme importance in the last years. The idea is to integrate biosensor technology and nanotechnology with stem cell research and with tissue engineering. Engineered tissues are integrated with biosensing technology to obtain microdevices for detecting cellular responses to external stimuli, monitoring the quality of the microenvironment (e.g., metabolites, nutrients), and supporting diverse cellular requirements. This research on 3D-functional engineered tissues is expected to develop knowledge of tissue construction and their functions and relation with some human diseases. Integration of fully functional tissues with microscale biosensor technology allowed us to obtain “organs-on-a-chip”. These chips could be used in pharmaceutical assays and could be a step toward the ultimate goal of producing in vitro drug testing systems crucial to the medicine and pharmaceutical industry.
|DAMOC · ‘Diabetes Approach by Multi-Organ-on-a-Chip’ (2017-2021)||ERC||Javier Ramón|
|BLOC · Benchtop NMR for Lab-on-Chip (2020-2022)||European Comission FET-Open||Javier Ramón|
|INDUCT · Fabrication of a biomimetic in vitro model of the intestinal tube muscle wall: smooth muscle-on-a-chip (2018-2020)||MINECO||Javier Ramón|
Privately funded projects
|Tatami · Therapeutic targeting of MBNL microRNAs as innovative treatments for myotonic dystrophy||Fundació bancaria “La Caixa”||Javier Ramón|
Velasco, Ferran, Fernandez-Costa, Juan M., Neves, Luisa, Ramon Azcon, Javier, (2020). Volumetric CNT-doped Gelatin-Cellulose scaffold for skeletal muscle tissue engineering Nanoscale Advances ahead,
Ortega, María A., Fernández-Garibay, Xiomara, Castaño, Albert G., De Chiara, Francesco, Hernández-Albors, Alejandro, Balaguer-Trias, Jordina, Ramón-Azcón, Javier, (2019). Muscle-on-a-chip with an on-site multiplexed biosensing system for in situ monitoring of secreted IL-6 and TNF-α Lab on a Chip 19, 2568-2580
de Goede, M., Dijkstra, M., Obregón, R., Ramón-Azcón, J., Martínez, Elena, Padilla, L., Mitjans, F., Garcia-Blanco, S. M., (2019). Al2O3 microring resonators for the detection of a cancer biomarker in undiluted urine Optics Express 27, (13), 18508-18521
De Chiara, F., Checcllo, C. U., Ramón-Azcón, J., (2019). High protein diet and metabolic plasticity in non-alcoholic fatty liver disease: Myths and truths Nutrients 11, (12), 2985
Hernández-Albors, Alejandro, Castaño, Albert G., Fernández-Garibay, Xiomara, Ortega, María Alejandra, Balaguer, Jordina, Ramón-Azcón, Javier, (2019). Microphysiological sensing platform for an in-situ detection of tissue-secreted cytokines Biosensors and Bioelectronics: X 2, 100025
García-Lizarribar, Andrea, Fernández-Garibay, Xiomara, Velasco-Mallorquí, Ferran, Castaño, Albert G., Samitier, Josep, Ramon-Azcon, Javier, (2018). Composite biomaterials as long-lasting scaffolds for 3D bioprinting of highly aligned muscle tissue Macromolecular Bioscience 18, (10), 1800167
Ino, Kosuke, Nashimoto, Yuji, Taira, Noriko, Ramón-Azcon, Javier, Shiku, Hitoshi, (2018). Intracellular electrochemical sensing Electroanalysis 30, (10), 2195-2209
de Goede, M., Chang, L., Dijkstra, M., Obregón, R., Ramón-Azcon, J., Martínez, Elena, Padilla, L., Adan, J., Mitjans, F., García-Blanco, S.M., (2018). Al2O3 Microresonator based passive and active biosensors ICTON 2018 20th International Conference on Transparent Optical Networks , IEEE Computer Society (Bucharest, Romania) , 8473820
de Goede, M., Chang, L., Dijkstra, M., Obregón, R., Ramón-Azcon, J., Martínez, Elena, Padilla, L., Adan, J., Mitjans, F., García-Blanco, S.M., (2018). Al2O3 Mmicroresonators for passive and active sensing applications Sensors 2018 Optical Sensors , OSA - The Optical Society (Zurich, Switzerland) Part F110, 1-2
Mohammadi, M. H., Obregón, R., Ahadian, S., Ramón-Azcón, J., Radisic, M., (2017). Engineered muscle tissues for disease modeling and drug screening applications Current Pharmaceutical Design , 23, (20), 2991-3004
Obregón, R., Ramón-Azcón, J., Ahadian, S., (2017). Nanofiber composites in blood vessel tissue engineering Nanofiber Composites for Biomedical Applications (ed. Ramalingam, M., Ramakrishna, S.), Elsevier (Duxford, UK) Woodhead Publishing Series in Biomaterials, 483-506
(See full publication list in ORCID)
Micro and nanofabrication techniques:
- 3D microstructures on hydrogel materials
- Mini-bioreactor for 3D cell culture
- Microelectrodes fabrication
- Synthesis and chemical modification of polymers and surfaces
- Dielectrophoretic cells and micro particles manipulation
- Optical Microscopes (white light/epifluorescence)
- Electrochemical techniques (Potentiometric/Amperometric/Impedance spectroscopy)
- Immunosensing techniques (Fluorescence ELISA/Colorimetric ELISA/magneto ELISA)
- Microfluidic systems (High precision syringe pumps/Peristaltic pumps/Micro valves)
- Biological safety cabinet (class II)
- Epifluorescence microscope for live-cell imaging
Access to the Nanotechnology Platform (IBEC Core Facilities): equipment for hot embossing lithography, polymer processing and photolithography, chemical wet etching, e-beam evaporation and surface characterization (TOF-SIMS)
Access to the Scientific and Technological Centers (University of Barcelona): equipment for surface analysis (XPS, AFM, XRD), organic structures characterization (NMR) and microscopy techniques (SEM, TEM, confocal)
- Prof. Josep Samitier
- Dr. Elena Martinez
- Dr. Anna Novials
Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS)
- Dr. Ramon Gomís
Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS)
- Dr. Eduard Montanya
The Bellvitge Biomedical Research Institute (IDIBELL)
- Prof. Enric Bertran
Physics and Engineering of Amorphous Materials and Nanostructures (FEMAN), Department of Applied Physics, University of Barcelona
Researchers from the Institute for Bioengineering of Catalonia (IBEC) have developed an innovative scaffold that allows muscle tissues growth at the millimetre scale in the laboratory.
This technology opens the door to potential applications in fields such as organ transplantation and engineering, drug screening and disease modelling.
Javier Ramón, Group Leader of the “Biosensors for Bioengineering” group at IBEC, has been appointed new Research Professor at the Catalan Institution for Research and Advanced Studies, ICREA. Currently IBEC hosts 8 ICREA Professors out of 22 group leaders.
Since last April 1, Dr. Javier Ramón, Group Leader at IBEC, has become part of the ICREA Research Professors community. ICREA is a foundation funded by the Catalan Government aimed at recruiting the most extraordinary and talented international scientific researchers. With this appointment, IBEC hosts 8 ICREA Professors and 2 ICREA Academia (UB affiliated professors), one of the highest numbers among all research centres in Catalonia.
A group of researchers from the Institute for Bioengineering of Catalonia (IBEC) leads the European project BLOC, an initiative led by researchers Javier Ramón and Irene Marco that seeks to evaluate the response to different drugs in metabolic diseases using organ-in-a- chip by using nuclear magnetic resonance (NMR). For this, the consortium will have a budget of almost 3 million euros, financed by the Horizon 2020 FET Open program.
Irene Marco explains at BigVan, the scientific section of La Vanguardia journal, how thanks to microfluidics and research based on the use of “organ-on-a-chip” devices, we can go a step forward towards personalized medicine.
During the 29th to 31st of October, IBEC participated in the fourth edition of “INDUSTRY: From Needs to Solutions”, the international meeting dedicated to 3D printing, and also the HELTHIO Days where Josep Samitier moderated the round table on 3D printing applications in healthcare.
In its fourth edition, IN(3D)USTRY becomes INDUSTRY to include more industrial sectors, the main goal is to cover the entire value chain and provide intelligent manufacturing solutions. The institute had a stand in the exhibition area, where the representatives of the IBEC Technology Transfer office welcomed the interested visitors to learn more about the 3D bioprinting capabilities of IBEC.
The Biosensors for bioengineering group led by Javier Ramón has developed a sensing platform for the in-situ detection of tissue-secreted pro-inflammatory molecules, the so-called cytokines. This new methodology opens a new door in the understanding of metabolic-disorders such those found in muscular diseases, as well as the development of drug-screening applications.
Although 40% of total body mass is skeletal muscle tissue, there is no specialized clinical doctor for the treatment of muscular diseases, according to the American Medical Association. The research group of Dr. Javier Ramón at IBEC works to fill this gap between muscle disorders and ad hoc therapies.
This weekend Javier Ramon’s European Research Council-funded project, DAMOC, was one of eight highlighted in a special exhibition in Madrid to mark the ERC’s tenth anniversary.
Alcobendas’ Museo Nacional de Ciencia y Tecnología (MUNCYT) displayed the most “outstanding” projects led by researchers in Spain as part of a full weekend of activities to celebrate the first decade of the prestigious funding body, which was launched in 2007 by the European Union and has funded nearly 7,000 researchers, among them six Nobel Prize winners.
IBEC’s Dr. Javier Ramón is one of just six researchers in Catalonia to have been awarded a 2016 Starting Grant by the European Research Council (ERC).
The senior researcher in the Biomimetic Systems for Cell Engineering group won funding for his project ‘Diabetes Approach by Multi-Organ-on-a-Chip’ (DAMOC) from Europe’s most prestigious funding body.
With the support, which will last for up to five years, Javier will start a new line to design a innovative new tool to test drugs for diabetes. As well as improving drug testing approaches, the multi-organ-on-a-chip device will provide new therapies to prevent the loss of beta cell mass and defects in the glucose uptake in skeletal muscle associated with type 2 diabetes.
“This project will give me the opportunity to have a multidisciplinary group of researchers working together from the beginning in a synchronized way, the most rewarding experience that a researcher can have,” he says.