A study led by IBEC researchers from the Nanobioengineering group, uses a functional predictive biomarker to anticipate the effect of treatments against rhabdomyosarcoma, the most common soft-tissue cancer affecting childhood and adolescence.
This advance can help in predicting treatment efficiency thus, avoiding tumor resistance and decreasing undesired secondary effects.
The new 3D hydrogels provide high rates of cell proliferation, as they mimic lymph nodes, where T-cells reproduce in vivo. A new project, led by researchers from ICMAB and IBEC, and with the collaboration of VHIO and UIC, wants to transfer this technology to hospitals.
Cancer immunotherapy is based on using and strengthening the patient’s own immune system to recognize and fight tumor cells, without damaging healthy tissues.
Researchers from the Institute for Bioengineering of Catalonia (IBEC) have developed an innovative scaffold that allows muscle tissues growth at the millimetre scale in the laboratory.
This technology opens the door to potential applications in fields such as organ transplantation and engineering, drug screening and disease modelling.
A team of researchers from the Institute for Bioengineering of Catalonia (IBEC) has discovered that strains of the bacterium Pseudomonas aeruginosa isolated from patients are more persistent than laboratory strains and propose a molecular mechanism to explain intracellular survival.
The study, published in the journal Virulence, finds that the class II ribonucleotide reductase enzyme (RNR) plays a key role in frequent lung infections, for example, those that occur in patients with cystic fibrosis.
Researchers from the Institute for Bioengineering of Catalonia (IBEC) have participated in a study led by Imperial College London in which the role of cyclin-dependent protein kinase 5 (CDKL5) in pain perception has been uncovered.
The defective version of the gene that produces this protein is behind CDKL5 deficiency disorder, a rare disease with no cure for which effective treatments will now be testable in mouse model, thanks to the results of this work.
A paper published in Nano Letters describes the engineering and functionality of a biocompatible and biodegradable nanomotor. This hybrid structure, which is composed of an organic exterior, propels itself using inorganic nanoparticles acting as an engine that the researchers have synthesized inside the nanomotor.
The research was led by Jan van Hest and Laoi Abdelmohsen from the Institute of Complex Molecular Systems at TU/e in collaboration with Samuel Sánchez from the Institute for Bioengineering of Catalonia (IBEC) in Barcelona, as well as researchers based in China and the UK.
Experts in bioengineering and informatics, including IBEC´s Associated Researcher Maria-Pau Ginebra, have published a paper where the researchers propose the creation of tools based on Artificial Intelligence for the development of biomaterials in Nature Reviews Materials.
Nature Reviews Materials journal has published an article signed by scientists from the Barcelona Supercomputing Center (BSC), the Universitat Politècnica de Catalunya (UPC) and the Institute for Bioengineering of Catalonia (IBEC) outlining the great possibilities that artificial intelligence offers towards the progress in the design and development of biomaterials.