We develop different Systems ranging from active nanoparticles (nanobots), 3D Bioprinted Actuators and flexible biosensors. We are interested in fundamental studies of active matter, the use of nanobots for future nanomedicine and environmental applications and the bioengineering of new devices based on hybrid systems.
The use of enzyme catalysis is emerging as an attractive alternative to power micro- and nanomachines due to their unique features including biocompatibility, versatility and fuel bioavailability. Our group has demonstrated the use of different enzymes, including urease and glucose oxidase, to generate active propulsion of nano– and microparticles, paving the way towards new applications of artificial active matter in biomedicine. We have recently demonstrated that using enzyme-powered nanomotors can enhance anti-cancer drug delivery in vitro, improve the targeting of 3D bladder cancer spheroids and sense their surrounding environment. We are also interested in understanding the fundamental aspects underlying the motion of biocatalytic microswimmers for a safe and efficient design of micro- and nanomotors.
Self-sensing enzyme-powered micromotors equipped with pH responsive DNA nanoswitches
T Patino, A Porchetta, A Jannasch, A Lladó, T Stumpp, E Schäffer, F Ricci,
Nano letters (2019) DOI: 10.1021/acs.nanolett.8b04794
Targeting 3D Bladder Cancer Spheroids with Urease-Powered Nanomotors
AC Hortelão, R Carrascosa, N Murillo-Cremaes, T Patiño, S Sánchez
ACS nano (2019), 13, 429-439
Fundamental Aspects of Enzyme-Powered Micro-and Nanoswimmers
T Patiño, X Arqué, R Mestre, L Palacios, S Sánchez
Accounts of chemical research (2018) 51, 2662-2671
Influence of enzyme quantity and distribution on the self-propulsion of non-Janus urease-powered micromotors
Tania Patiño, Natalia Feiner-Gracia, Xavier Arqué, Albert Miguel-López, Anita Jannasch, Tom Stumpp, Erik Schäffer, Lorenzo Albertazzi, Samuel Sánchez
Journal of the American Chemical Society (2018), 140, 7896-7903
Enzyme‐Powered Nanobots Enhance Anticancer Drug Delivery
AC Hortelão, T Patiño, A Perez‐Jiménez, À Blanco, S Sánchez
Advanced Functional Materials (2018), 28, 1705086
3D BioPrinted Soft Robotics
In the research line of soft bio-hybrid robotics, we explore the integration of biological tissue and artificial materials at larger length scales. In particular, we take advantage of the 3D bioprinting technique to develop bio-robotic systems composed of skeletal muscle cells embedded in biocompatible hydrogels, which can be 3D bioprinted alongside other artificial materials. These materials can act as scaffolds, support, or flexible parts, as well as be responsive upon certain stimuli. By controlling the contractions of skeletal muscle cells via electric fields, we can measure the forces exerted by these bio-actuators against artificial 3D-printed posts. Using this setup, we have performed studies on the adaptability of bio-actuators after applying different training protocols and we have observed how their force generation and gene expression can adapt to the frequency of stimulation and stiffness of the artificial posts.
Force Modulation and Adaptability of 3D‐Bioprinted Biological Actuators Based on Skeletal Muscle Tissue
Rafael Mestre, Tania Patiño, Xavier Barceló, Shivesh Anand, Ariadna Pérez‐Jiménez, Samuel Sánchez
Advanced Materials Technologies (2018): 1800631
Miniaturized soft bio-hybrid robotics: a step forward into healthcare applications
Tania Patino, Rafael Mestre, Samuel Sánchez
Lab Chip, 2016 1619, 3626-3630
Active matter in complex systems
We study colloidal suspensions of Pt-coated silica particles as a model system of synthetic active matter. These systems have mostly been studied in homogeneous environments until now. Our interest lies in observing these systems in more complex settings, such as near interfaces, complex media or with flow involved. Since the self-propelled particles generate chemical and hydrodynamic fields around them, they interact in complex ways with flows and nearby surfaces that often leads to interesting behaviour. We could find, for instance, that close to solid surfaces they achieve a stable ‘gliding’ state which could be exploited to develop a system for guiding micro-nano motors using topographical features as shown with our micropatterned ratchets. When flow is present, particles also behave different as they reorient perpendicular to the flow.
Topographical Pathways Guide Chemical Microswimmers
Juliane Simmchen, Jaideep Katuri, William E. Uspal, Mihail N. Popescu, Mykola Tasinkevych, and Samuel Sánchez
Nature Communications 2016 7 , 10598
Directed Flow of Micromotors through Alignment Interactions with Micropatterned Ratchets
Jaideep Katuri, David Caballero, Raphael Voituriez, Josep Samitier and Samuel Sanchez
ACS Nano 2018 12, 7282-7291
Cross-stream migration of active particles
Jaideep Katuri, William E. Uspal, Juliane Simmchen, Albert Miguel-López, Samuel Sánchez
Science Advances 2018 (4)
Environmental applications of micro-nano motors
Micromotors can remove a wide variety of pollutants from contaminated water.
Artificial micromotors, based on bubble self-propulsion have demonstrated to be able to mix solutions and enhance chemical reactions while they swim. These micromotors are mostly based on two main structures, tubular and spherical.
First, we have designed tubular micromotors, which use hydrogen peroxide as a fuel, using different techniques such as, ‘rolling-up’ and electrodeposition. ‘Rolling-up’ microjets with a functional iron-based layer can generate and actively transport free radicals in the solution performing the degradation of organic dyes via Fenton-like reactions in presence of hydrogen peroxide. On the other hand, electrodeposited microjets, which are smaller than their ‘roll-up’ counterparts, contain graphene-oxide on the outside working as ‘heavy metal scrubbers’. In this case, the metal is adsorbed and removed from the contaminated water. The metal can thereafter be desorbed and the microjets used again.
In order to target other water pollution problems, such as microorganism contamination, we have developed spherical microbots that can kill bacteria while they swim. These microbots have a Janus structure based on spherical magnesium microparticles, able to dissolve in water producing hydrogen bubbles, covered in one of their faces by Fe, Au and AgNPs which provide magnetic, bacteria attachment and bactericidal properties to the microjets.
Towards scaling-up of the micromotor synthesis for cleaning large volumes of water, we have fabricated micromotors using exclusively chemical methods such as, precipitation, reduction and sol-gel chemistry. These micromotors are based on a silica microtubular structure which contains an inner-layer of a catalytic material (PtNPs or MnO2) capable of removing pollutants efficiently from water while they swim in the presence of hydrogen peroxide. The external decoration of these structures with magnetic nanoparticles provides for good magnetic control. Finally, magnetic and catalytic micromotors formed by the aggregation of cobalt ferrite nanoparticles were synthesized to remove antibiotics from water. All these micromotors, due to their magnetic properties can be removed from the solution after finishing their targeting action by the application of an external magnetic field.
Reusable and Long-Lasting Active Microcleaners for Heterogeneous Water Remediation
Jemish Parmar, Diana Vilela, Eva Pellicer, Daniel Esqué-de los Ojos, Jordi Sort, and Samuel Sánchez
Advanced Functional Materials 2016 26, 4152–4161
Graphene-Based Microbots for Toxic Heavy Metal Removal and Recovery from Water
Diana Vilela, Jemish Parmar, Yongfei Zeng, Yanli Zhao, and Samuel Sánchez
Nano Letters 2016 16, 2860-2866
Microbots Decorated with Silver Nanoparticles Kill Bacteria in Aqueous Media
Diana Vilela, Morgan M. Stanton, Jemish Parmar, and Samuel Sánchez
ACS Appl. Mater. Interfaces, 2017, 9, 22093–22100
(Flexible) Biosensors for non-invasive Point-of-Care diagnostics
Point-of-care diagnostics allows decentralizing clinical diagnostic practices and monitoring health out of specialized hospital settings. Advantages of such decentralization are improved quality of life of patients, enhanced therapeutic efficacy thanks to more frequent tests, and lower overall cost of the health system. We develop flexible biochemical sensors for non-invasive and cost-effective monitoring of analytes in biological fluids alternative to blood, e.g. sweat, tears, and saliva. We combine electrochemical electrochemical sensors with microfluidics and electronics to achieve fully integrated devices, that are well suited for low-cost, portable and user-friendly medical diagnostics.
Inkjet printed flexible non-enzymatic glucose sensor for tear fluid analysis
Agostino Romeo, Ana Moya, Tammy S. Leung, Gemma Gabriel, Rosa Villa and Samuel Sánchez
Applied Materials Today, 2018 10, 133-141
Smart biosensors for multiplexed and fully integrated point-of-care diagnostics
Agostino Romeo, Tammy Sue Leung, and Samuel Sánchez
Lab Chip, 2016 16, 1957-1961
Flexible sensors for biomedical technology
Diana Vilela, Agostino Romeo, and Samuel Sánchez
Lab Chip, 2016 16, 402-408
Samuel Sánchez Ordóñez | Group Leader / ICREA Research Professor
Maria Demestre Viladevall | Senior Researcher
Maria Guix Noguera | Postdoctoral Researcher
Morgane Valles | Postdoctoral Researcher
Xavier Arqué Roca | PhD Student
Ana Candida Lopes Hortelão | PhD Student
Rafael Mestre Castillo | PhD Student
Lucas Santiago Palacios Ruiz | PhD Student
Judith Fuentes Llanos | Research Assistant
Guido Van Moolenbroek | Research Assistant
Angel Blanco Blanes | Laboratory Technician
Paula Piñeiro Varela | Masters Student
Veronika Magdanz | Visiting Researcher
Tania Patiño Padial | Visiting Researcher
Marco de Corato | Postdoctoral Researcher
|LABPATCH · Lab-in-a-patch for PKU self-assessment (2018 – 2020)||EU Commission / ERC – PoC||Samuel Sánchez|
|SGR Grups de recerca consolidats (2017-2020)||AGAUR / SGR||Samuel Sánchez|
|BOTSinFLUIDS · Movimiento de nanorobots biocatalíticos en fluidos biológicos y medio complexo para un transporte eficiente de fármacos (2019 – 2021)||MICIU / Retos investigación: Proyectos I+D||Samuel Sánchez|
Privately funded projects
|MEDIROBOTS · MEdical micro- and nano-Robots for Molecular Imaging (2018 – 2021)||Fundación BBVA||Samuel Sánchez|
|TERANOBOTS · Nanorobots for bladder cancer theranostics (2019 – 2020)||Obra Social La Caixa / Caixaimpluse||Samuel Sánchez|
|Effect of a New cosmectic active ingredient in the regulation of muscular function (2019-2021)||Lipotec, S.A.U.||Samuel Sánchez|
|Efecto de un nuevo ingrediente activo nutraceutico en la regulación de la relajación muscular (2019-2020)||Lipofoods, S.L.U||Samuel Sánchez|
|LT-NRBS Lab-in-a-tube and Nanorobotic biosensors (2013-2017)||ERC Starting Grant||Samuel Sánchez|
|Microcleaners Active microcleaners for water remediation (2016-2018)||ERC Proof of Concept Grant||Samuel Sánchez|
|MicroDia Sistemas Lab-on-a-chip basados en micro-nanomotores para el diagnóstico de enfermedades (2016-2018)||MINECO, Retos investigación: Proyectos I+D||Samuel Sánchez|
|ENZWIM Nanomotores de nanopartículas mesoporosas impulsados por enzimas||MINECO, Explora||Samuel Sánchez|
|Mesoporous Silica Micro/Nano-motors as Active Drug Delivery Vehicles (2014-2016)||Alexander von Humboldt Foundation||Ma Xing|
|LOC-Systems based on Nano/Micromachines for Food Safety Applications (2014-2016)||Alexander von Humboldt Foundation||Diana Vilela|
For a list of publications prior to joining IBEC, visit the MPI for Intelligent Systems website.
Xu, D., Wang, Y., Liang, C., You, Y., Sanchez, S., Ma, X., (2020). Self-propelled micro/nanomotors for on-demand biomedical cargo transportation Small Early View
Horteläo, Ana C., Carrascosa, Rafael, Murillo-Cremaes, Nerea, Patiño, Tania, Sánchez, Samuel, (2019). Targeting 3D bladder cancer spheroids with urease-powered nanomotors ACS Nano 13, (1), 429-439
Patino, Tania, Porchetta, Alessandro, Jannasch, Anita, Lladó, Anna, Stumpp, Tom, Schäffer, Erik, Ricci, Francesco, Sánchez, Samuel, (2019). Self-sensing enzyme-powered micromotors equipped with pH-responsive DNA nanoswitches Nano Letters 19, (6), 3440-3447
Wang, Lei, Hortelão, Ana C., Huang, Xin, Sánchez, Samuel, (2019). Lipase-powered mesoporous silica nanomotors for triglyceride degradation Angewandte Chemie International Edition 58, (24), 7992-7996
Arqué, Xavier, Romero-Rivera, Adrian, Feixas, Ferran, Patiño, Tania, Osuna, Sílvia, Sánchez, Samuel, (2019). Intrinsic enzymatic properties modulate the self-propulsion of micromotors Nature Communications 10, (1), 2826
Mestre, Rafael, Patiño, Tania, Barceló, Xavier, Anand, Shivesh, Pérez-Jiménez, Ariadna, Sánchez, Samuel, (2019). Force modulation and adaptability of 3D-bioprinted biological actuators based on skeletal muscle tissue Advanced Materials Technologies 4, (2), 1800631
Llopis-Lorente, A., Garcií-Fernández, A., Murillo-Cremaes, N., Hortelão, A. C., Patinño, T., Villalonga, R., Sancenón, F., Martínez-Máñer, R., Sánchez, S., (2019). Enzyme-powered gated mesoporous silica nanomotors for on-command intracellular payload delivery ACS Nano 13, (10), 12171-12183
Palacios, L. S., Katuri, J., Pagonabarraga, I., Sánchez, S., (2019). Guidance of active particles at liquid-liquid interfaces near surfaces Soft Matter 15, (32), 6581-6588
Mestre, R., Patiño, T., Guix, M., Barceló, X., Sánchez, S., (2019). Design, optimization and characterization of bio-hybrid actuators based on 3D-bioprinted skeletal muscle tissue Biomimetic and Biohybrid Systems 8th International Conference, Living Machines 2019 (Lecture Notes in Computer Science) , Springer International Publishing (Nara, Japan) 11556, 205-215
Martin, Aida, Vilela, Diana, Escarpa, Alberto, (2019). Carbon nanomaterials for advanced analytical micro- and nanotechnologies Carbon-based Nanomaterials in Analytical Chemistry (ed. Garcia, C. D., Crevillén, A. G, Escarpa, A.), The Royal Society of Chemistry (London, UK) , 200-240
Patiño, Tania, Arqué, Xavier, Mestre, Rafael, Palacios, Lucas, Sánchez, Samuel, (2018). Fundamental aspects of enzyme-powered micro- and nanoswimmers Accounts of Chemical Research 51, (11), 2662–2671
Hortelão, A. C., Patiño, T., Perez-Jiménez, A., Blanco, A., Sánchez, S., (2018). Enzyme-powered nanobots enhance anticancer drug delivery Advanced Functional Materials 28, 1705086
Wang, Xu, Sridhar, Varun, Guo, Surong, Talebi, Nahid, Miguel-López, Albert, Hahn, Kersten, van Aken, Peter A., Sánchez, Samuel, (2018). Fuel-free nanocap-like motors actuated under visible light Advanced Functional Materials 28, (25), 1705862
Patiño, Tania, Feiner-Gracia, Natalia, Arqué, Xavier, Miguel-López, Albert, Jannasch, Anita, Stumpp, Tom, Schäffer, Erik, Albertazzi, Lorenzo, Sánchez, Samuel, (2018). Influence of enzyme quantity and distribution on the self-propulsion of non-Janus urease-powered micromotors Journal of the American Chemical Society 140, (25), 7896-7903
Parmar, Jemish, Vilela, Diana, Villa, Katherine, Wang, Joseph, Sanchez, Samuel, (2018). Micro- and nanomotors as active environmental microcleaners and sensors Journal of the American Chemical Society 140, (30), 9317-9331
Katuri, Jaideep, Caballero, David, Voituriez, R., Samitier, Josep, Sanchez, Samuel, (2018). Directed flow of micromotors through alignment interactions with micropatterned ratchets ACS Nano 12, (7), 7282-7291
Vilela, Diana, Cossío, Unai, Parmar, Jemish, Martínez-Villacorta, Angel M., Gómez-Vallejo, Vanessa, Llop, Jordi, Sánchez, Samuel, (2018). Medical imaging for the tracking of micromotors ACS Nano 12, (2), 1120-1227
Katuri, Jaideep, Uspal, William E., Simmchen, Juliane, Miguel-López, Albert, Sánchez, Samuel, (2018). Cross-stream migration of active particles Science Advances 4, (1), eaao1755
Xuan, Mingjun, Mestre, Rafael, Gao, Changyong, Zhou, Chang, He, Qiang, Sánchez, Samuel, (2018). Noncontinuous super-diffusive dynamics of a light-activated nanobottle motor Angewandte Chemie International Edition 57, (23), 6838-6842
Villa, Katherine, Parmar, Jemish, Vilela, Diana, Sánchez, Samuel, (2018). Metal-oxide-based microjets for the simultaneous removal of organic pollutants and heavy metals ACS Applied Materials and Interfaces 10, (24), 20478-20486
Romeo, Agostino, Moya, Ana, Leung, Tammy S., Gabriel, Gemma, Villa, Rosa, Sánchez, Samuel, (2018). Inkjet printed flexible non-enzymatic glucose sensor for tear fluid analysis Applied Materials Today 10, 133-141
Villa, Katherine, Parmar, Jemish, Vilela, Diana, Sanchez, Samuel, (2018). Core-shell microspheres for the ultrafast degradation of estrogen hormone at neutral pH RSC Advances 8, (11), 5840-5847
Mestre, Rafael, Patiño, Tania, Barceló, Xavier, Sanchez, Samuel, (2018). 3D Bioprinted muscle-based bio-actuators: Force adaptability due to training Biomimetic and Biohybrid Systems 7th International Conference, Living Machines 2018 (Lecture Notes in Computer Science) , Springer International Publishing (Paris, France) 10928, 316-320
Parmar, J., Villa, K., Vilela, D., Sánchez, S., (2017). Platinum-free cobalt ferrite based micromotors for antibiotic removal Applied Materials Today 9, 605-611
Katuri, Jaideep, Ma, Xing, Stanton, Morgan M., Sánchez, Samuel, (2017). Designing micro- and nanoswimmers for specific applications Accounts of Chemical Research 50, (1), 2-11
Stanton, Morgan M., Park, Byung-Wook, Vilela, Diana, Bente, Klaas, Faivre, Damien, Sitti, Metin, Sanchez, Samuel, (2017). Magnetotactic bacteria powered biohybrids target E. coli biofilms ACS Nano 11, (10), 9968-9978
Stanton, Morgan M., Sánchez, Samuel, (2017). Pushing bacterial biohybrids to in vivo applications Trends in Biotechnology , 35, (10), 910-913
Stanton, M. M., Park, B. W., Miguel-López, A., Ma, X., Sitti, M., Sánchez, S., (2017). Biohybrid microtube swimmers driven by single captured bacteria Small 13, (19), 1603679
Vilela, D., Stanton, M. M., Parmar, J., Sánchez, S., (2017). Microbots decorated with silver nanoparticles kill bacteria in aqueous media ACS Applied Materials & Interfaces 9, (27), 22093-22100
Vilela, D., Hortelao, A. C., Balderas-Xicohtencatl, R., Hirscher, M., Hahn, K., Ma, X., Sanchez, S., (2017). Facile fabrication of mesoporous silica micro-jets with multi-functionalities Nanoscale 9, 13990
Ma, Xing, Sánchez, Samuel, (2017). Self-propelling micro-nanorobots: challenges and future perspectives in nanomedicine Nanomedicine 12, (12), 1363-1367
Simmchen, Juliane, Baeza, Alejandro, Miguel-Lopez, Albert, Stanton, Morgan M., Vallet-Regi, Maria, Ruiz-Molina, Daniel, Sánchez, Samuel, (2017). Dynamics of novel photoactive AgCl microstars and their environmental applications ChemNanoMat , 3, (1), 65-71
Ma, X., Sánchez, S., (2017). Bio-catalytic mesoporous Janus nano-motors powered by catalase enzyme Tetrahedron , 73, (33), 4883-4886
Parmar, Jemish, Vilela, Diana, Sanchez, Samuel, (2016). Tubular microjets: Fabrication, factors affecting the motion and mechanism of propulsion The European Physical Journal: Special Topics , 225, (11), 2255-2267
Ma, Xing, Horteläo, Ana C., Patiño, Tania, Sánchez, Samuel, (2016). Enzyme catalysis to power micro/nanomachines ACS Nano 10, (10), 9111–9122
Ma, Xing, Wang, Xu, Hahn, Kersten, Sánchez, Samuel, (2016). Motion control of urea powered biocompatible hollow microcapsules ACS Nano 10, (3), 3597-3605
Ma, Xing, Jang, Seungwook, Popescu, Mihail N., Uspal, William E., Miguel-López, Albert, Hahn, Kersten, Kiam, Dong-Pyo, Sánchez, Samuel, (2016). Reversed Janus micro/nanomotors with internal chemical engine ACS Nano 10, (9), 8751-8759
Ma, Xing, Hortelao, Ana C., Miguel-López, Albert, Sánchez, Samuel, (2016). Bubble-free propulsion of ultrasmall tubular nanojets powered by biocatalytic reactions Journal of the American Chemical Society 138, (42), 13782–13785
Vilela, Diana, Parmar, Jemish, Zeng, Yongfei, Zhao, Yanli, Sánchez, Samuel, (2016). Graphene based microbots for toxic heavy metal removal and recovery from water Nano Letters 16, (4), 2860-2866
Parmar, J., Vilela, D., Pellicer, E., Esqué-de los Ojos, D., Sort, J., Sánchez, S., (2016). Reusable and long-lasting active microcleaners for heterogeneous water remediation Advanced Functional Materials 26, (23), 4152-4161
Simmchen, J., Katuri, J., Uspal, W. E., Popescu, M. N., Tasinkevych, M., Sánchez, S., (2016). Topographical pathways guide chemical microswimmers Nature Communications 7, 10598
Maggi, Claudio, Simmchen, Juliane, Saglimbeni, Filippo, Katuri, Jaideep, Dipalo, Michele, De Angelis, Francesco, Sánchez, Samuel, Di Leonardo, Roberto, (2016). Self-assembly of micromachining systems powered by Janus micromotors Small 12, (4), 446-451
Katuri, J., Seo, K. D., Kim, D. S., Sánchez, S., (2016). Artificial micro-swimmers in simulated natural environments Lab on a Chip 16, (7), 1101-1105
Vilela, Diana, Romeo, Agostino, Sánchez, Samuel, (2016). Flexible sensors for biomedical technology Lab on a Chip 16, (3), 402-408
Safdar, M., Janis, J., Sánchez, S., (2016). Microfluidic fuel cells for energy generation Lab on a Chip 16, (15), 2754-2758
Patino, T., Mestre, R., Sánchez, S., (2016). Miniaturized soft bio-hybrid robotics: a step forward into healthcare applications Lab on a Chip 16, (19), 3626-3630
Caballero, D., Katuri, J., Samitier, J., Sánchez, S., (2016). Motion in microfluidic ratchets Lab on a Chip 16, (23), 4477-4481
Romeo, A., Leung, T. S., Sánchez, S., (2016). Smart biosensors for multiplexed and fully integrated point-of-care diagnostics Lab on a Chip 16, (11), 1957-1961
Stanton, Morgan M., Simmchen, Juliane, Ma, Xing, Miguel-López, Albert, Sánchez, Samuel, (2016). Biohybrid Janus motors driven by Escherichia coli Advanced Materials Interfaces , 3, (2), 1500505
Ma, X., Jannasch, A., Albrecht, U. R., Hahn, K., Miguel-López, A., Schäffer, E., Sánchez, S., (2015). Enzyme-powered hollow mesoporous Janus nanomotors Nano Letters 15, (10), 7043-7050
Ma, X., Hahn, K., Sánchez, S., (2015). Catalytic mesoporous janus nanomotors for active cargo delivery Journal of the American Chemical Society 137, (15), 4976-4979
Sánchez, S., Soler, L., Katuri, J., (2015). Chemically powered micro- and nanomotors Angewandte Chemie - International Edition , 54, (4), 1414-1444
Ma, X., Katuri, J., Zeng, Y., Zhao, Y., Sánchez, S., (2015). Surface conductive graphene-wrapped micromotors exhibiting enhanced motion Small 11, (38), 5023–5027
Choudhury, Udit, Soler, Lluis, Gibbs, John, Sánchez, Samuel, Fischer, Peer, (2015). Surface roughness-induced speed increase for active Janus micromotors Chemical Communications 51, 8660-8663
Stanton, M. M., Trichet-Paredes, C., Sánchez, S., (2015). Applications of three-dimensional (3D) printing for microswimmers and bio-hybrid robotics Lab on a Chip 15, (7), 1634-1637
Stanton, M. M., Samitier, J., Sánchez, S., (2015). Bioprinting of 3D hydrogels Lab on a Chip 15, (15), 3111-3115
Seo, K. D., Kim, D. S., Sánchez, S., (2015). Fabrication and applications of complex-shaped microparticles via microfluidics Lab on a Chip 15, (18), 3622-3626
Parmar, Jemish, Jang, Seungwook, Soler, Lluis, Kim, Dong-Pyo, Sánchez, Samuel, (2015). Nano-photocatalysts in microfluidics, energy conversion and environmental applications Lab on a Chip 15, 2352-2356
Wang, Lei, Sánchez, Samuel, (2015). Self-assembly via microfluidics Lab on a Chip 15, (23), 4383-4386
Arayanarakool, Rerngchai, Meyer, Anne K., Helbig, Linda, Sánchez, Samuel, Schmidt, Oliver G., (2015). Tailoring three-dimensional architectures by rolled-up nanotechnology for mimicking microvasculatures Lab on a Chip 15, 2981-2989
Mendes, Rafael Gregorio, Koch, Britta, Bachmatiuk, Alicja, Ma, Xing, Sánchez, Samuel, Damm, Christine, Schmidt, Oliver G., Gemming, Thomas, Eckert, Jurgen, Rummeli, Mark H., (2015). A size dependent evaluation of the cytotoxicity and uptake of nanographene oxide Journal of Materials Chemistry B , 3, (12), 2522-2529
Paxton, W., Sánchez, S., Nitta, T., (2015). Guest editorial: Special issue micro- and nanomachines IEEE Transactions on Nanobioscience , 14, (3), 258-259
Seo, K. D., Kwak, B. K., Sánchez, S., Kim, D. S., (2015). Microfluidic-assisted fabrication of flexible and location traceable organo-motor IEEE Transactions on Nanobioscience , 14, (3), 298-304
Khalil, I. S. M., Magdanz, V., Sánchez, S., Schmidt, O. G., Misra, S., (2015). Precise localization and control of catalytic janus micromotors using weak magnetic fields International Journal of Advanced Robotic Systems , 12, (2), 1-7
- Autolab Galvostat/potentiostat (Metrohm)
- Dynamic light scattering (Wyatt)
- Langmuir Blodgett (KSV NIMA)
- Inverted Fluorescent microscope with cell incubator, galvo stage for 3D tracking (Leica DMi8); Inverted Fluorescent microscope (Leica DMI3000B); Upright microscope (Leica)
- Video camera (1000+ fps) (Hamamatsu)
- High speed camera (10000+ fps) (Vision Research)
- CCD video camera (100fps) (Thorlabs)
- Centrifuge (Eppendorf)
- UV- Visible spectrometer (Analytik Jena)
- 3D printer (Formlabs)
- Wave form source; Voltage amplifier (Tabor Electronics)
- DC power supply (Hameg)
- Oscilloscope (Rigol)
- Testtube heater; Eppendorf tube Shaker (Hach)
- Oxygen Plasma cleaner (Deiner Electronics)
- TOC Analyser (Analytik Jena)
- Spin coater (Laurell)
- High vacuum film deposition system (Leica Microsystems)
- UV irradiation system (Vilber Lourmat)
- Portable potentiostat-galvanostat and multiplexer (PalmSens)
- Sonicator (Branson)
- Thermolyne Furnace (Thermo Scientific)
- Hydrothermal Reactor (Berghof)
- Inkredible+ 3D Bioprinter (Cellink)
- Sonicator (VWR)
- DUO 3 Dual Stage Rotary Vane Vacuum Pump (Pfeiffer Vacuum)
- Orbital Shaker-Incubator ES-20 (Biosan)
- AL4000 Aladdin Double Syringe Pump (WPI)
- MFCS-EZ Microfluidic flow control system(Fluigent)
- Prof. D.P. Kim
National Center of Applied Microfluidic Chemistry, Department of Chemical Engineering, POSTECH (Pohang University of Science and Technology), Korea
- Prof. S. Dietrich, Dr. M. Popescu, M. Tasinkevych, Dr. W. Uspal
Theory of Soft Condensed Matter, MPI for Intelligent Systems, Stuttgart, Germany
- Prof. M. Sitti
Physical Intelligence department, MPI for Intelligent Systems
- Prof. R. Di Leonardo
Universtità La Sapienza, Rome, Italy
- Prof. J. Sort, Dr. Eva Pellicer
Physics Department, Universitat Autònoma de Bellaterra (UAB), Spain
- Dr. D. Esqué
The School of Materials, The University of Manchester, UK
- Dr. J. Llop
CIC BiomaGUNE, San Sebastián, Spain
- Prof. F. Ricci
Dipartimento di Scienze e Tecnologie Chimiche Università di Roma Tor Vergata, Rome, Italy
- Dr. Ll. Soler
Institute of Energy Technologies (INTE), UPC (ETSEIB), Barcelona
- Prof. E. Shäffer
Center for Plant Molecular Biology (ZMBP), University of Tübingen, Germany
- Dr. L. Albertazzi
Nanoscopy group, IBEC
- Prof. J. Samitier
NanoBioengineering Group, IBEC
- Dr. D. Caballero
University of Minho, Portugal
- Prof. R. Voituriez
CNRS/Université Pierre et Marie Curie, Paris, France
- Dr. G. Gabriel and Prof. R. Villa
Instituto de Microelectrónica de Barcelona, IMB-CNM (CSIC)
- Dr. R. Artuch
Laboratorio de enfermedades metabólicas hereditarias, Hospital Sant Joan de Déu, Barcelona.
We are happy to receive CVs and enquiries from talented individuals. Prospective students and staff are encouraged to contact us to discuss possibilities. Please feel free to suggest new projects, areas of research or new ideas.
Current job openings in the group are listed on the jobs page.
The nanoBio&Med2018 International Conference opened today with IBEC Director Josep Samitier chairing the first round of talks, in which group leader Samuel Sanchez is the first speaker.
Eight IBECers were in the Netherlands on 13th and 14th September for the first ever IBEC-ICMS Symposium, ‘NanoSens&Med’.
Today IBEC welcomed the new Director General of Research, Development, and Innovation of the Spanish Ministry of Science, Innovation and Universities (MINECO) to meet some of the group leaders and hear about their research.
IBEC group leader and ICREA research professor Samuel Sánchez is quoted in an article in Inside Science about enzymes that could counteract the effects of toxic nerve agents.
An IBEC project has won funding from the BBVA Foundation under its ‘Ayudas a Equipos de Investigación en Biomedicina’ funding programme.
IBEC’s Smart-Nano-Bio-Devices and Nanobioengineering groups have joined forces to solve the problem of random movement of micro- and nanomotors.
Two IBEC groups have clubbed together to combine their expertise and reveal new knowledge that could advance the design of micro- and nanomotors for applications in health.
Samuel Sánchez features in a long article in Retina magazine (El País).
Researchers working at IBEC and the Max Planck Institute for Intelligent Systems have developed nanomotors that are powered by a fuel-free, biofriendly and unlimited power source: light.
IBEC researchers have demonstrated that their enzyme-powered nanobots show a marked improvement in drug delivery efficiency over passive ones.
In the Què Qui Com program that aired yesterday on Canal 33, Samuel Sánchez, ICREA research professor at IBEC, explained the work being done in his group to develop nanorobots that can release drugs in a controlled manner.
A paper by IBEC’s Smart nano-bio-devices group addresses the problem of biofilms, the “microbe cities” that enhance cell-to-cell communication for bacteria, allowing infection to thrive and increasing the chances of evading the immune system. In the body, they can be found in a wide variety of microbial infections, such as in the lungs of cystic fibrosis or chronic obstructive pulmonary disease patients.
Samuel Sanchez has broken his own Guinness World Record for the smallest jet engine.
Samuel Sanchez is featured in an article in QUO magazine that discusses how chemistry and technology are combining to offer sustainable solutions for society and the planet.
The press release about Samuel Sanchez’s recent paper in ACS Applied Materials & Interfaces that describes tiny robots that can remove disease-causing bacteria from water got coverage in La Vanguardia’s Big Vang section, rTVE and other outlets.
ACS highlights our work on using microbots to kill pathogenic bacteria.
This weekend Samuel Sanchez was interviewed by El Punt Avui and ABC talking about nanorobots and the future of medicine.
Premi Nacional de Recerca winners Samuel Sanchez and ICFO’s Lluís Torner appeared on El Punt Avui’s L’Illa de Robinson programme on Wednesday, after the awards ceremony on Tuesday night. It’s just one example of the huge amount of press coverage there’s been about the awards.
IBEC group leader and ICREA research professor Samuel Sánchez was one of the five honorees at the ceremony of the Premis Nacionals de Recerca 2016 of the Fundació Catalana per a la Recerca i la Innovació (FCRI).
IBEC group leader and ICREA researcher Samuel Sánchez has been announced as the winner of this year’s Premi Nacional de Recerca al Talent Jove (National Research Award for Young Talent) from the Generalitat de Catalunya and the Catalan Foundation for Research and Innovation (FCRI).
IBEC group leader and ICREA research professor Samuel Sanchez’s latest nanojets have set a new world record for the smallest man-made jet engine ever.
An audience of nearly a hundred enjoyed a special public seminar by IBEC group leader and ICREA research professor Samuel Sánchez.
The Smart nano-bio-devices group leader’s talk, Nanorobots de la ciència-ficció a la realitat, which took place in the PCB’s Sala Dolors Aleu, was one of this year’s Setmana de la Ciència events.
Group leader and ICREA professor Samuel Sanchez appeared as a guest on the La 2 magazine programme Tips on Wednesday 19th.
Group leader Samuel Sanchez appeared on Telediario, channel 1’s news programme, commenting about the work of the Nobel Prize winners for chemistry, which were announced in the first week of October.
“Els Premiats FPdGi Olga Felip, Samuel Sánchez, Ignasi Belda i Mohamed El Amrani, conversen amb l’humorista Juan Carlos Ortega”
A round table discussion involving Samuel Sánchez, last year’s winner of the Princess of Girona Foundation (FPdGi) Award for Scientific Research, and other former winners was filmed at the recent FPdGi 2016 awards ceremony in Girona.
Samuel Sanchez features in an article in ARA magazine this week which marks the 15th anniversary of ICREA.
A video of Samuel Sánchez taking part in April’s Festival de Nanociencia y Nanotecnología.
Samuel Sánchez’s recent NanoLetters paper about self-propelled tiny ‘microbots’ that can remove lead from contaminated water gets lots of coverage this week by news channels such as Discovery News, Phys.org and several more.
Samuel Sánchez featured on Oficiorama, a programme devoted to the technology of the future, which airs on TV2 on Saturdays.
IBEC researchers have developed a self-propelled tiny ‘microbot’ that can remove lead from contaminated water.
Samuel Sanchez and the part of his lab that resides at the MPI for Intelligent Systems in Stuttgart feature in a chapter of a video series by El Pais, La Carrera Especial.
IBEC group leader and ICREA research professor Samuel Sánchez is the winner of this year’s edition of the Círculo Ecuestre’s Premio Joven Relevante.
Samuel Sanchez’s recent Nature Communications paper on micromotors that use surface variations for docking and guiding was the subject of an article in El Mundo today.
IBEC group leader and ICREA research professor Samuel Sánchez was one of two scientists taking part in a studio discussion on La Sexta Noche on Saturday, in a segment about what it’s like to be a talented young scientist or entrepreneur in the financial climate of Spain today.
Researchers at the Institute for Bioengineering of Catalonia (IBEC), the Max-Planck Institute for Intelligent Systems and the University of Stuttgart have revealed in an article in Nature Communications today that micromotors can be guided using tiny topographical patterns on the surfaces over which they swim.
Samuel Sánchez’s nanorobots are one of the “Seis aplicaciones robóticas que no conocías” described in an article in El País today.
IBEC group leader and ICREA research professor Samuel Sánchez is to receive an ERC Proof of Concept grant to explore the innovation potential of some of his research. His project “Active microcleaners for water remediation” (Microcleaners) will tackle the huge rise in pollutants in water that has been the result of the massive growth in industrial, domestic and agricultural activities.
“Entrevista al investigador Samuel Sánchez Ordóñez: “Son smart nano-bio-devices. Nanorobots autopropulsados”
Article and video at Informativos.net.
Following his appearance at Emtech France in Toulouse in December 2015, Samuel Sánchez featured in French daily newspaper La Tribune.
(See the video of Samuel’s talk at Emtech France here).
An IBEC researcher and his collaborators have taken the next step in their quest to achieve safe micromotors for medical drug and cargo delivery by developing a version that is powered by bacteria.
El País has published a “Ciencia en Español” video interview with Samuel Sanchez featuring footage of his nanorobots, which can be seen whizzing through through liquid using the expulsion of oxygen bubbles as propulsion.
A video about Samuel Sanchez and his work is the latest addition to the El País/Vodafone One video archive. The collection helps promote the public understanding of technology, scientific advances and innovations, and how they affect our daily lives.
IBEC group leader Samuel Sánchez was one of the experts invited to attend the Innovators Under 35 European Summit in Brussels last week, a gathering of the European winners of MIT Technology Review’s “Innovators under 35” list.
IBEC group leader Samuel Sanchez was one of the experts and professionals invited to take part in CEDE’s “Talento en Crecimiento” event at the Palacio de Exposiciones y Congresos in A Coruña at the beginning of the month.
Researchers at IBEC and their collaborators have made a breakthrough in nanomotors for applications in medicine by developing the first ever fully biocompatible self-propelling particles that are powered by enzymes that consume biological fuels, such as glucose.
IBEC group leader Samuel Sánchez was the subject of La Vanguardia’s “Big Vang questionnaire”.
On 30 June the rtve science programme Lab24 featured an interview with new IBEC group leader Samuel Sánchez, who describes his research on micro and nanomotors.
IBEC group leader Samuel Sánchez was the subject of an article in El Periódico on Tuesday.
An article about new IBEC group leader Samuel Sanchez by Josep Corbella in La Vanguardia yesterday talks about the ‘brain gain’ of having the nanotechnologist return to Catalonia after several years in Japan, the USA and Germany.
El Periódico features an interview with Samuel Sànchez following the announcement last week that he has been awarded the Premio Fundación Princesa de Girona Investigación Científica 2015.
IBEC group leader Samuel Sánchez is this year’s winner of the Premio Fundación Princesa de Girona Investigación Científica for his advances in in the field of nanotechnology. Samuel’s work was recognised in particular for his pioneering design of self-propelled nanorobots that could improve the accuracy of drug delivery, as well as having potential environmental applications.
New IBEC group leader Samuel Sánchez appears in articles in El Mundo and El Periodico today, talking about his career so far, his new appointment at IBEC and the work he will be continuing on micro- and nanomotors.
One of the world’s top researchers – and a record-breaker – in the field of nano- and microrobots is coming to Barcelona to continue his career. The Institute for Bioengineering of Catalonia (IBEC) welcomes Dr. Samuel Sánchez (Terrassa, 1980), who is taking up a new Group Leader position there this month.
Xing Ma, Ana C. Hortelão, Tania Patiño, and Samuel Sánchez (2016). Enzyme Catalysis To Power Micro/Nanomachines. ACS Nano, Volume 10, Issue 10, pp. 9053–9762
Advanced Materials Interfaces
Morgan M. Stanton, Juliane Simmchen, Xing Ma, Albert Miguel-López, Samuel Sánchez* (2015). Bio-hybrid Janus Motors Driven by Escherichia coli. Adv Mat Interfaces
Xing Ma, Jaideep Katuri, Yongfei Zeng, Yanli Zhao and Samuel Sanchez (2015). Janus Micromotors: Surface Conductive Graphene-Wrapped Micromotors Exhibiting Enhanced Motion. Small, 11, 38, p4989