BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Institute for Bioengineering of Catalonia - ECPv6.3.5//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-WR-CALNAME:Institute for Bioengineering of Catalonia X-ORIGINAL-URL:https://ibecbarcelona.eu X-WR-CALDESC:Events for Institute for Bioengineering of Catalonia REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:Europe/Madrid BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20190331T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20191027T010000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=Europe/Madrid:20190711T120000 DTEND;TZID=Europe/Madrid:20190711T140000 DTSTAMP:20240329T100227 CREATED:20190704T134259Z LAST-MODIFIED:20190709T132751Z UID:67121-1562846400-1562853600@ibecbarcelona.eu SUMMARY:PhD Thesis Defence: Víctor González Tarragó DESCRIPTION:Control of integrin-mediated mechanoresponse by binding partners and force loading rates\nVíctor González Tarragó\, Cellular and Molecular Mechanobiology group \nThis thesis is a study on the integrin-mediated mechanoresponse by binding partners and force loading rates. Regarding the binding partners\, here we demonstrate an alternative and counter-intuitive mechanism\, by which another adaptor protein (ZO-1) promotes activation but decreases mechanical resistance. Because such mechanical regulation is bound to impact in downstream mechanosensing processes\, this provides an interesting and novel way to regulate cell adhesion\, mechanoresponse\, and function in general. Regarding the force loading rates\, our results show that force loading rates drive mechanosensing by increasing reinforcement and adhesion growth at the local adhesion level\, in a talin-dependent way. However\, if mechanically induced deformations are too high or too fast\, the cytoskeleton fluidizes\, thereby decreasing force loading rates and mechanosensing. This provides a unifying mechanism to understand how cells respond not only to directly applied forces\, but also to passive mechanical stimuli such as tissue rigidity or ECM ligand distribution. Further\, it also provides a framework to understand how the seemingly opposed concepts of reinforcement and fluidization are coupled to drive mechanosensing. \n  \n  \n  \nShare this...FacebookPinterestTwitterLinkedin URL:https://ibecbarcelona.eu/event/phd-thesis-defence-victor-gonzalez-tarrago/ LOCATION:Aula 14\, Faculty of Medicine (Campus Clínic)\, Barcelona\, Spain CATEGORIES:PhD Thesis Defence END:VEVENT END:VCALENDAR