Staff member


Davia Prischich

PhD Student
Nanoprobes and Nanoswitches
dprischich@ibecbarcelona.eu
+34 934 031 127
Staff member publications

Prischich, Davia, Gomila, Alexandre M. J., Milla-Navarro, Santiago, Sangüesa, Gemma, Diez-Alarcia, Rebeca, Preda, Beatrice, Matera, Carlo, Batlle, Montserrat, Ramírez, Laura, Giralt, Ernest, Hernando, Jordi, Guasch, Eduard, Meana, J. Javier, de la Villa, Pedro, Gorostiza, Pau, (2020). Adrenergic modulation with photochromic ligands Angewandte Chemie International Edition Online ahead of print

Adrenoceptors are ubiquitous and mediate important autonomic functions as well as modulating arousal, cognition and pain on a central level. Understanding these physiological processes and their underlying neural circuits requires manipulating adrenergic neurotransmission with high spatio-temporal precision. Here we present a first generation of photochromic ligands (adrenoswitches) obtained via azologization of a class of cyclic amidines related to the known ligand clonidine. Their pharmacology, photochromism, bioavailability and lack of toxicity allow for broad biological applications, as demonstrated by controlling locomotion in zebrafish and pupillary responses in mice.

Keywords: Adrenergic, Neurotransmitters, Azo compounds, Biological activity, Photochromism.